Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology

Glycosylphosphatidylinositol (GPI) is a posttranslational glycolipid modification of proteins that anchors proteins in lipid rafts on the cell surface. Although some GPI-anchored proteins (GPI-APs), including the prion protein PrP(C), have a glycan side chain composed of N-acetylgalactosamine (GalNA...

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Detalles Bibliográficos
Autores principales: Hirata, Tetsuya, Kobayashi, Atsushi, Furuse, Tamio, Yamada, Ikuko, Tamura, Masaru, Tomita, Hiroyuki, Tokoro, Yuko, Ninomiya, Akinori, Fujihara, Yoshitaka, Ikawa, Masahito, Maeda, Yusuke, Murakami, Yoshiko, Kizuka, Yasuhiko, Kinoshita, Taroh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913354/
https://www.ncbi.nlm.nih.gov/pubmed/35151686
http://dx.doi.org/10.1016/j.jbc.2022.101720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913354/
https://www.ncbi.nlm.nih.gov/pubmed/35151686
http://dx.doi.org/10.1016/j.jbc.2022.101720

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