Potent, p53-independent induction of NOXA sensitizes MLL-rearranged B-cell acute lymphoblastic leukemia cells to venetoclax

The prognosis for B-cell precursor acute lymphoblastic leukemia patients with Mixed-Lineage Leukemia (MLL) gene rearrangements (MLLr BCP-ALL) is still extremely poor. Inhibition of anti-apoptotic protein BCL-2 with venetoclax emerged as a promising strategy for this subtype of BCP-ALL, however, lack...

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Detalles Bibliográficos
Autores principales: Fidyt, Klaudyna, Pastorczak, Agata, Cyran, Julia, Crump, Nicholas T., Goral, Agnieszka, Madzio, Joanna, Muchowicz, Angelika, Poprzeczko, Martyna, Domka, Krzysztof, Komorowski, Lukasz, Winiarska, Magdalena, Harman, Joe R., Siudakowska, Karolina, Graczyk-Jarzynka, Agnieszka, Patkowska, Elzbieta, Lech-Maranda, Ewa, Mlynarski, Wojciech, Golab, Jakub, Milne, Thomas A., Firczuk, Malgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913358/
https://www.ncbi.nlm.nih.gov/pubmed/35091682
http://dx.doi.org/10.1038/s41388-022-02196-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913358/
https://www.ncbi.nlm.nih.gov/pubmed/35091682
http://dx.doi.org/10.1038/s41388-022-02196-y

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