Cargando…

Potent, p53-independent induction of NOXA sensitizes MLL-rearranged B-cell acute lymphoblastic leukemia cells to venetoclax

The prognosis for B-cell precursor acute lymphoblastic leukemia patients with Mixed-Lineage Leukemia (MLL) gene rearrangements (MLLr BCP-ALL) is still extremely poor. Inhibition of anti-apoptotic protein BCL-2 with venetoclax emerged as a promising strategy for this subtype of BCP-ALL, however, lack...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fidyt, Klaudyna, Pastorczak, Agata, Cyran, Julia, Crump, Nicholas T., Goral, Agnieszka, Madzio, Joanna, Muchowicz, Angelika, Poprzeczko, Martyna, Domka, Krzysztof, Komorowski, Lukasz, Winiarska, Magdalena, Harman, Joe R., Siudakowska, Karolina, Graczyk-Jarzynka, Agnieszka, Patkowska, Elzbieta, Lech-Maranda, Ewa, Mlynarski, Wojciech, Golab, Jakub, Milne, Thomas A., Firczuk, Malgorzata
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913358/ https://www.ncbi.nlm.nih.gov/pubmed/35091682 http://dx.doi.org/10.1038/s41388-022-02196-y

Ejemplares similares

Targeting the thioredoxin system as a novel strategy against B‐cell acute lymphoblastic leukemia
por: Fidyt, Klaudyna, et al.
Publicado: (2019)

Mechanisms of Immune Evasion in Acute Lymphoblastic Leukemia
por: Pastorczak, Agata, et al.
Publicado: (2021)

P1376: IDENTIFICATION OF SURFACEOME CHANGES IN CD19 CAR-T THERAPY-RESISTANT LYMPHOMA CELLS
por: Krawczyk, Marta, et al.
Publicado: (2023)

Inhibition of thioredoxin-dependent H(2)O(2) removal sensitizes malignant B-cells to pharmacological ascorbate
por: Graczyk-Jarzynka, Agnieszka, et al.
Publicado: (2018)

Philadelphia Chromosome-Positive Leukemia in the Lymphoid Lineage—Similarities and Differences with the Myeloid Lineage and Specific Vulnerabilities
por: Komorowski, Lukasz, et al.
Publicado: (2020)

A Specific CD44lo CD25lo Subpopulation of Regulatory T Cells Inhibits Anti-Leukemic Immune Response and Promotes the Progression in a Mouse Model of Chronic Lymphocytic Leukemia
por: Goral, Agnieszka, et al.
Publicado: (2022)

New insights into redox homeostasis as a therapeutic target in B-cell malignancies
por: Graczyk-Jarzynka, Agnieszka, et al.
Publicado: (2017)

cROSsing the Line: Between Beneficial and Harmful Effects of Reactive Oxygen Species in B-Cell Malignancies
por: Domka, Krzysztof, et al.
Publicado: (2020)

Efficient chimeric antigen receptor targeting of a central epitope of CD22
por: Casey, Nicholas Paul, et al.
Publicado: (2023)

The Great War of Today: Modifications of CAR-T Cells to Effectively Combat Malignancies
por: Zhylko, Andriy, et al.
Publicado: (2020)

Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents
por: Bajor, Malgorzata, et al.
Publicado: (2018)

CAR-T Cells Shoot for New Targets: Novel Approaches to Boost Adoptive Cell Therapy for B Cell-Derived Malignancies
por: Marhelava, Katsiaryna, et al.
Publicado: (2022)

Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer
por: Wachowska, Małgorzata, et al.
Publicado: (2011)

PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells
por: Bajor, Malgorzata, et al.
Publicado: (2022)

Typical and Atypical Inducers of Lysosomal Cell Death: A Promising Anticancer Strategy
por: Domagala, Antoni, et al.
Publicado: (2018)

Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells
por: Bajor, Malgorzata, et al.
Publicado: (2020)

Inhibition of IDO leads to IL-6-dependent systemic inflammation in mice when combined with photodynamic therapy
por: Wachowska, Malgorzata, et al.
Publicado: (2020)

The Tumor Microenvironment—A Metabolic Obstacle to NK Cells’ Activity
por: Domagala, Joanna, et al.
Publicado: (2020)

Inhibition of autophagy sensitizes cancer cells to Photofrin-based photodynamic therapy
por: Domagala, Antoni, et al.
Publicado: (2018)

Selection of an optimal promoter for gene transfer in normal B cells
por: Winiarska, Magdalena, et al.
Publicado: (2017)

PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress
por: Klopotowska, Marta, et al.
Publicado: (2022)

The Immune Landscape of Breast Cancer: Strategies for Overcoming Immunotherapy Resistance
por: Retecki, Kuba, et al.
Publicado: (2021)

Targeting Negative and Positive Immune Checkpoints with Monoclonal Antibodies in Therapy of Cancer
por: Marhelava, Katsiaryna, et al.
Publicado: (2019)

β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties
por: Fidyt, Klaudyna, et al.
Publicado: (2016)

Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma
por: Trzeciecka, Anna, et al.
Publicado: (2015)

Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity
por: Wachowska, Malgorzata, et al.
Publicado: (2015)

Immune Evasion as the Main Challenge for Immunotherapy of Cancer
por: Zagozdzon, Radoslaw, et al.
Publicado: (2022)

Why are so many MLL lysine methyltransferases required for normal mammalian development?
por: Crump, Nicholas T., et al.
Publicado: (2019)

Neutrophil Elastase Defects in Congenital Neutropenia
por: Rydzynska, Zuzanna, et al.
Publicado: (2021)

Discrepant NOXA (PMAIP1) transcript and NOXA protein levels: a potential Achilles' heel in mantle cell lymphoma
por: Dengler, M A, et al.
Publicado: (2014)

Intraurethral co-transplantation of bone marrow mesenchymal stem cells and muscle-derived cells improves the urethral closure
por: Burdzinska, Anna, et al.
Publicado: (2018)

Long-lasting reduction in clonogenic potential of colorectal cancer cells by sequential treatments with 5-azanucleosides and topoisomerase inhibitors
por: Pawlak, Alicja, et al.
Publicado: (2016)

The Importance of the Double Product in the Six-Minute Walk Test to Predict Myocardial Function
por: Domka-Jopek, Elżbieta, et al.
Publicado: (2018)

NOXA as critical mediator for drug combinations in polychemotherapy
por: Ehrhardt, H, et al.
Publicado: (2012)

Regulatory T cells contribute to the immunosuppressive phenotype of neutrophils in a mouse model of chronic lymphocytic leukemia
por: Goral, Agnieszka, et al.
Publicado: (2023)

P808: CONGENITAL NEUTROPENIA PREVALENCE AMONG POLISH CHILDREN – SUMMARY OF A NATIONWIDE GENETIC SCREENING CAMPAIGN
por: Bąbol-Pokora, K., et al.
Publicado: (2022)

The kinetics of blast clearance are associated with copy number alterations in childhood B-cell acute lymphoblastic leukemia
por: Urbańska, Zuzanna, et al.
Publicado: (2022)

The Relationship between Body Composition and Muscle Tone in Children with Cerebral Palsy: A Case-Control Study
por: Więch, Paweł, et al.
Publicado: (2020)

Aspirin Induced Glioma Apoptosis through Noxa Upregulation
por: Chang, Cheng-Yi, et al.
Publicado: (2020)

NOXA Is Important for Verticillium dahliae’s Penetration Ability and Virulence
por: Zhu, Xiaohan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_29e5ek9sr6l9ve0kqgccg4lqd3