Loss of NFE2L3 protects against inflammation-induced colorectal cancer through modulation of the tumor microenvironment

We investigated the role of the NFE2L3 transcription factor in inflammation-induced colorectal cancer. Our studies revealed that Nfe2l3(−/−) mice exhibit significantly less inflammation in the colon, reduced tumor size and numbers, and skewed localization of tumors with a more pronounced decrease of...

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Detalles Bibliográficos
Autores principales: Saliba, James, Coutaud, Baptiste, Makhani, Kiran, Epstein Roth, Noam, Jackson, Jennie, Park, Joo Yeoun, Gagnon, Natascha, Costa, Paolo, Jeyakumar, Thiviya, Bury, Marina, Beauchemin, Nicole, Mann, Koren K., Blank, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913363/
https://www.ncbi.nlm.nih.gov/pubmed/35091681
http://dx.doi.org/10.1038/s41388-022-02192-2

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