Efficient DNA Repair Mitigates Replication Stress Resulting in Less Immunogenic Cytosolic DNA in Radioresistant Breast Cancer Stem Cells

Cancer stem cells (CSCs) are a major cause of tumor therapy failure. This is mainly attributed to increased DNA repair capacity and immune escape. Recent studies have shown that functional DNA repair via homologous recombination (HR) prevents radiation-induced accumulation of DNA in the cytoplasm, t...

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Detalles Bibliográficos
Autores principales: Meyer, Felix, Engel, Anna Maria, Krause, Ann Kristin, Wagner, Tim, Poole, Lena, Dubrovska, Anna, Peitzsch, Claudia, Rothkamm, Kai, Petersen, Cordula, Borgmann, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913591/
https://www.ncbi.nlm.nih.gov/pubmed/35280989
http://dx.doi.org/10.3389/fimmu.2022.765284

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