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Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study
Inhaled corticosteroids (ICS) have been associated with increased risk of pneumonia. Their impact on respiratory virus infections is unclear. We performed a post-hoc analysis of the FLUVAC cohort, a multicenter prospective cohort study of adults hospitalized with influenza-like illness (ILI) during...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913614/ https://www.ncbi.nlm.nih.gov/pubmed/35273311 http://dx.doi.org/10.1038/s41598-022-08089-0 |
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author | Luque-Paz, David Tattevin, Pierre Loubet, Paul Bénézit, François Thibault, Vincent Lainé, Fabrice Vanhems, Philippe Amour, Selilah Lina, Bruno Duval, Xavier L’Honneur, Anne-Sophie Fidouh, Nadhira Vallejo, Christine Alain, Sophie Galtier, Florence Foulongne, Vincent Lagathu, Gisèle Lenzi, Nezha Lesieur, Zineb Launay, Odile Jouneau, Stéphane |
author_facet | Luque-Paz, David Tattevin, Pierre Loubet, Paul Bénézit, François Thibault, Vincent Lainé, Fabrice Vanhems, Philippe Amour, Selilah Lina, Bruno Duval, Xavier L’Honneur, Anne-Sophie Fidouh, Nadhira Vallejo, Christine Alain, Sophie Galtier, Florence Foulongne, Vincent Lagathu, Gisèle Lenzi, Nezha Lesieur, Zineb Launay, Odile Jouneau, Stéphane |
author_sort | Luque-Paz, David |
collection | PubMed |
description | Inhaled corticosteroids (ICS) have been associated with increased risk of pneumonia. Their impact on respiratory virus infections is unclear. We performed a post-hoc analysis of the FLUVAC cohort, a multicenter prospective cohort study of adults hospitalized with influenza-like illness (ILI) during six consecutive influenza seasons (2012–2018). All patients were tested for respiratory virus infection by multiplex PCR on nasopharyngeal swabs and/or bronchoalveolar lavage. Risk factors were identified by logistic regression analysis. Among the 2658 patients included, 537 (20.2%) were treated with ICS before admission, of whom 282 (52.5%, 282/537) tested positive for at least one respiratory virus. Patients on ICS were more likely to test positive for non-influenza respiratory viruses (25.1% vs. 19.5%, P = 0.004), especially for adenovirus (aOR 2.36, 95% CI 1.18–4.58), and respiratory syncytial virus (aOR 2.08, 95% CI 1.39–3.09). Complications were reported in 55.9% of patients on ICS (300/537), primarily pneumonia (171/535, 32%). Among patients on chronic ICS who tested positive for respiratory virus, 14.2% (40/282) were admitted to intensive care unit, and in-hospital mortality rate was 2.8% (8/282). Chronic use of ICS is associated with an increased risk of adenovirus or RSV infections in patients admitted for ILI. |
format | Online Article Text |
id | pubmed-8913614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-89136142022-03-11 Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study Luque-Paz, David Tattevin, Pierre Loubet, Paul Bénézit, François Thibault, Vincent Lainé, Fabrice Vanhems, Philippe Amour, Selilah Lina, Bruno Duval, Xavier L’Honneur, Anne-Sophie Fidouh, Nadhira Vallejo, Christine Alain, Sophie Galtier, Florence Foulongne, Vincent Lagathu, Gisèle Lenzi, Nezha Lesieur, Zineb Launay, Odile Jouneau, Stéphane Sci Rep Article Inhaled corticosteroids (ICS) have been associated with increased risk of pneumonia. Their impact on respiratory virus infections is unclear. We performed a post-hoc analysis of the FLUVAC cohort, a multicenter prospective cohort study of adults hospitalized with influenza-like illness (ILI) during six consecutive influenza seasons (2012–2018). All patients were tested for respiratory virus infection by multiplex PCR on nasopharyngeal swabs and/or bronchoalveolar lavage. Risk factors were identified by logistic regression analysis. Among the 2658 patients included, 537 (20.2%) were treated with ICS before admission, of whom 282 (52.5%, 282/537) tested positive for at least one respiratory virus. Patients on ICS were more likely to test positive for non-influenza respiratory viruses (25.1% vs. 19.5%, P = 0.004), especially for adenovirus (aOR 2.36, 95% CI 1.18–4.58), and respiratory syncytial virus (aOR 2.08, 95% CI 1.39–3.09). Complications were reported in 55.9% of patients on ICS (300/537), primarily pneumonia (171/535, 32%). Among patients on chronic ICS who tested positive for respiratory virus, 14.2% (40/282) were admitted to intensive care unit, and in-hospital mortality rate was 2.8% (8/282). Chronic use of ICS is associated with an increased risk of adenovirus or RSV infections in patients admitted for ILI. Nature Publishing Group UK 2022-03-10 /pmc/articles/PMC8913614/ /pubmed/35273311 http://dx.doi.org/10.1038/s41598-022-08089-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Luque-Paz, David Tattevin, Pierre Loubet, Paul Bénézit, François Thibault, Vincent Lainé, Fabrice Vanhems, Philippe Amour, Selilah Lina, Bruno Duval, Xavier L’Honneur, Anne-Sophie Fidouh, Nadhira Vallejo, Christine Alain, Sophie Galtier, Florence Foulongne, Vincent Lagathu, Gisèle Lenzi, Nezha Lesieur, Zineb Launay, Odile Jouneau, Stéphane Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study |
title | Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study |
title_full | Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study |
title_fullStr | Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study |
title_full_unstemmed | Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study |
title_short | Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study |
title_sort | chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913614/ https://www.ncbi.nlm.nih.gov/pubmed/35273311 http://dx.doi.org/10.1038/s41598-022-08089-0 |
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