iRhom pseudoproteases regulate ER stress-induced cell death through IP(3) receptors and BCL-2

The folding capacity of membrane and secretory proteins in the endoplasmic reticulum (ER) can be challenged by physiological and pathological perturbations, causing ER stress. If unresolved, this leads to cell death. We report a role for iRhom pseudoproteases in controlling apoptosis due to persiste...

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Detalles Bibliográficos
Autores principales: Dulloo, Iqbal, Atakpa-Adaji, Peace, Yeh, Yi-Chun, Levet, Clémence, Muliyil, Sonia, Lu, Fangfang, Taylor, Colin W., Freeman, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913617/
https://www.ncbi.nlm.nih.gov/pubmed/35273168
http://dx.doi.org/10.1038/s41467-022-28930-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913617/
https://www.ncbi.nlm.nih.gov/pubmed/35273168
http://dx.doi.org/10.1038/s41467-022-28930-4

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