Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis

Microbiota-host interactions play critical roles in colorectal cancer (CRC) progression, however, the underlying mechanisms remain elusive. Here, we uncover that Fusobacterium nucleatum (F. nucleatum) induces a dramatic decline of m(6)A modifications in CRC cells and patient-derived xenograft (PDX)...

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Detalles Bibliográficos
Autores principales: Chen,, Shujie, Zhang, Lu, Li, Mengjie, Zhang, Ying, Sun, Meng, Wang, Lingfang, Lin, Jiebo, Cui, Yun, Chen, Qian, Jin, Chenqi, Li, Xiang, Wang, Boya, Chen, Hao, Zhou, Tianhua, Wang, Liangjing, Hsu, Chih-Hung, Zhuo, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913623/
https://www.ncbi.nlm.nih.gov/pubmed/35273176
http://dx.doi.org/10.1038/s41467-022-28913-5

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