Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control

Non-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, yet the pathophysiological mechanisms underpinning this bidirectional relationship remain unresolved. Using proteomic approaches, we interrogate hepatocyte protein secretion in two models of murine NASH to understand how li...

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Detalles Bibliográficos
Autores principales: Montgomery, Magdalene K., Bayliss, Jacqueline, Nie, Shuai, De Nardo, William, Keenan, Stacey N., Miotto, Paula M., Karimkhanloo, Hamzeh, Huang, Cheng, Schittenhelm, Ralf B., Don, Anthony S., Ryan, Andrew, Williamson, Nicholas A., Ooi, Geraldine J., Brown, Wendy A., Burton, Paul R., Parker, Benjamin L., Watt, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913628/
https://www.ncbi.nlm.nih.gov/pubmed/35273160
http://dx.doi.org/10.1038/s41467-022-28889-2

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