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Decreased serum iron concentration and total iron binding capacity are associated with serious Crohn’s disease

This study aimed to investigate whether serum indicators related to iron stores in the body are associated with clinical and endoscopic disease severity. Eighty-four patients with Crohn’s disease (CD) and twenty-four healthy volunteers were included. The indicators related to iron stores were detect...

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Autores principales: Su, Jingling, Ren, Yandan, Liu, Lupeng, Hu, Yiqun, Shi, Huaxiu, Ren, Jianlin, Xie, Chenxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913652/
https://www.ncbi.nlm.nih.gov/pubmed/35273280
http://dx.doi.org/10.1038/s41598-022-07948-0
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author Su, Jingling
Ren, Yandan
Liu, Lupeng
Hu, Yiqun
Shi, Huaxiu
Ren, Jianlin
Xie, Chenxi
author_facet Su, Jingling
Ren, Yandan
Liu, Lupeng
Hu, Yiqun
Shi, Huaxiu
Ren, Jianlin
Xie, Chenxi
author_sort Su, Jingling
collection PubMed
description This study aimed to investigate whether serum indicators related to iron stores in the body are associated with clinical and endoscopic disease severity. Eighty-four patients with Crohn’s disease (CD) and twenty-four healthy volunteers were included. The indicators related to iron stores were detected within one week after endoscopic and CT enterography examinations. Patients were divided into three groups according to the CDAI(Crohn's disease activity index)scores. Serum iron levels were decreased in all groups (p < 0.05), and the values of remission group were higher than those of moderate group (p < 0.001). The total iron binding capacity(TIBC)values of the moderate group were lower than those of the controls and the other groups (p < 0.05). None of the indicators differed significantly among the patients classified by SES-CD (p > 0.05). Underweight, decreased serum iron and TIBC were independent risk factors for moderate clinical disease. Combined detection of decreased serum iron and TIBC was helpful in differentiating severe patients. The sensitivity and specificity were 32.7% and 100%, respectively (AUC = 0.812, p < 0.01). Decreases in serum iron and TIBC were associated with the clinical activity of CD. Combined detection of the two indicators was conducive to screening serious disease.
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spelling pubmed-89136522022-03-11 Decreased serum iron concentration and total iron binding capacity are associated with serious Crohn’s disease Su, Jingling Ren, Yandan Liu, Lupeng Hu, Yiqun Shi, Huaxiu Ren, Jianlin Xie, Chenxi Sci Rep Article This study aimed to investigate whether serum indicators related to iron stores in the body are associated with clinical and endoscopic disease severity. Eighty-four patients with Crohn’s disease (CD) and twenty-four healthy volunteers were included. The indicators related to iron stores were detected within one week after endoscopic and CT enterography examinations. Patients were divided into three groups according to the CDAI(Crohn's disease activity index)scores. Serum iron levels were decreased in all groups (p < 0.05), and the values of remission group were higher than those of moderate group (p < 0.001). The total iron binding capacity(TIBC)values of the moderate group were lower than those of the controls and the other groups (p < 0.05). None of the indicators differed significantly among the patients classified by SES-CD (p > 0.05). Underweight, decreased serum iron and TIBC were independent risk factors for moderate clinical disease. Combined detection of decreased serum iron and TIBC was helpful in differentiating severe patients. The sensitivity and specificity were 32.7% and 100%, respectively (AUC = 0.812, p < 0.01). Decreases in serum iron and TIBC were associated with the clinical activity of CD. Combined detection of the two indicators was conducive to screening serious disease. Nature Publishing Group UK 2022-03-10 /pmc/articles/PMC8913652/ /pubmed/35273280 http://dx.doi.org/10.1038/s41598-022-07948-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Su, Jingling
Ren, Yandan
Liu, Lupeng
Hu, Yiqun
Shi, Huaxiu
Ren, Jianlin
Xie, Chenxi
Decreased serum iron concentration and total iron binding capacity are associated with serious Crohn’s disease
title Decreased serum iron concentration and total iron binding capacity are associated with serious Crohn’s disease
title_full Decreased serum iron concentration and total iron binding capacity are associated with serious Crohn’s disease
title_fullStr Decreased serum iron concentration and total iron binding capacity are associated with serious Crohn’s disease
title_full_unstemmed Decreased serum iron concentration and total iron binding capacity are associated with serious Crohn’s disease
title_short Decreased serum iron concentration and total iron binding capacity are associated with serious Crohn’s disease
title_sort decreased serum iron concentration and total iron binding capacity are associated with serious crohn’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913652/
https://www.ncbi.nlm.nih.gov/pubmed/35273280
http://dx.doi.org/10.1038/s41598-022-07948-0
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