Cargando…
Novel indolic AMPK modulators induce vasodilatation through activation of the AMPK–eNOS–NO pathway
Endothelial adenosine monophosphate-activated protein kinase (AMPK) plays a critical role in the regulation of vascular tone through stimulating nitric oxide (NO) release in endothelial cells. Since obesity leads to endothelial dysfunction and AMPK dysregulation, AMPK activation might be an importan...
Autores principales: | Sanz-Gómez, Marta, Aledavood, Elnaz, Beroiz-Salaverri, Marina, Lagartera, Laura, Vega-Martín, Elena, Gil-Ortega, Marta, Cumella, Jose, Pérez, Concepción, Luque, Francisco Javier, Estarellas, Carolina, Fernández-Alfonso, María S., Castro, Ana |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913687/ https://www.ncbi.nlm.nih.gov/pubmed/35273216 http://dx.doi.org/10.1038/s41598-022-07077-8 |
Ejemplares similares
-
Structural basis of the selective activation of enzyme isoforms: Allosteric response to activators of β1- and β2-containing AMPK complexes
por: Aledavood, Elnaz, et al.
Publicado: (2021) -
Elucidating the Activation Mechanism of AMPK by Direct Pan-Activator PF-739
por: Aledavood, Elnaz, et al.
Publicado: (2021) -
Madagascine Induces Vasodilatation via Activation of AMPK
por: Chen, Dapeng, et al.
Publicado: (2016) -
Activation of eNOS by D-pinitol Induces an Endothelium-Dependent Vasodilatation in Mouse Mesenteric Artery
por: Moreira, Luciana N., et al.
Publicado: (2018) -
Recombinant Adiponectin Ameliorates Liver Ischemia Reperfusion Injury via Activating the AMPK/eNOS Pathway
por: Zhang, Chuanzhao, et al.
Publicado: (2013)