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Salmonella Salamae and S. Waycross isolated from Nile perch in Lake Victoria show limited human pathogenic potential

Non-enterica subspecies of Salmonella enterica are rarely associated with human infections. Paradoxically, food safety legislations consider the entire genus Salmonella as pathogenic to humans. Globally, large amounts of seafoods are rejected and wasted due to findings of Salmonella. To inform bette...

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Autores principales: Hounmanou, Yaovi Mahuton Gildas, Baniga, Zebedayo, García, Vanesa, Dalsgaard, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913728/
https://www.ncbi.nlm.nih.gov/pubmed/35273308
http://dx.doi.org/10.1038/s41598-022-08200-5
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author Hounmanou, Yaovi Mahuton Gildas
Baniga, Zebedayo
García, Vanesa
Dalsgaard, Anders
author_facet Hounmanou, Yaovi Mahuton Gildas
Baniga, Zebedayo
García, Vanesa
Dalsgaard, Anders
author_sort Hounmanou, Yaovi Mahuton Gildas
collection PubMed
description Non-enterica subspecies of Salmonella enterica are rarely associated with human infections. Paradoxically, food safety legislations consider the entire genus Salmonella as pathogenic to humans. Globally, large amounts of seafoods are rejected and wasted due to findings of Salmonella. To inform better food safety decisions, we investigated the pathogenicity of Salmonella Salamae 42:r- and Salmonella Waycross isolated from Nile perch from Lake Victoria. Genome-wide analysis revealed absence of significant virulence determinants including on key Salmonella pathogenicity islands in both serovars. In epithelial cells, S. Salamae showed a weak invasion ability that was lower than the invH mutant of S. Typhimiurium used as negative control. Similarly, S. Salamae could not replicate inside macrophages. Moreover, intracellular replication in S. Waycross strains was significantly lower compared to the wild type S. Typhimurium. Our findings suggest a low pathogenicity of S. Salamae reinforcing the existing literature that non-enterica subspecies are avirulent. We propose that food legislations and actions taken on findings of Salmonella are revisited to avoid wasting valuable sea- and other foods.
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spelling pubmed-89137282022-03-14 Salmonella Salamae and S. Waycross isolated from Nile perch in Lake Victoria show limited human pathogenic potential Hounmanou, Yaovi Mahuton Gildas Baniga, Zebedayo García, Vanesa Dalsgaard, Anders Sci Rep Article Non-enterica subspecies of Salmonella enterica are rarely associated with human infections. Paradoxically, food safety legislations consider the entire genus Salmonella as pathogenic to humans. Globally, large amounts of seafoods are rejected and wasted due to findings of Salmonella. To inform better food safety decisions, we investigated the pathogenicity of Salmonella Salamae 42:r- and Salmonella Waycross isolated from Nile perch from Lake Victoria. Genome-wide analysis revealed absence of significant virulence determinants including on key Salmonella pathogenicity islands in both serovars. In epithelial cells, S. Salamae showed a weak invasion ability that was lower than the invH mutant of S. Typhimiurium used as negative control. Similarly, S. Salamae could not replicate inside macrophages. Moreover, intracellular replication in S. Waycross strains was significantly lower compared to the wild type S. Typhimurium. Our findings suggest a low pathogenicity of S. Salamae reinforcing the existing literature that non-enterica subspecies are avirulent. We propose that food legislations and actions taken on findings of Salmonella are revisited to avoid wasting valuable sea- and other foods. Nature Publishing Group UK 2022-03-10 /pmc/articles/PMC8913728/ /pubmed/35273308 http://dx.doi.org/10.1038/s41598-022-08200-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hounmanou, Yaovi Mahuton Gildas
Baniga, Zebedayo
García, Vanesa
Dalsgaard, Anders
Salmonella Salamae and S. Waycross isolated from Nile perch in Lake Victoria show limited human pathogenic potential
title Salmonella Salamae and S. Waycross isolated from Nile perch in Lake Victoria show limited human pathogenic potential
title_full Salmonella Salamae and S. Waycross isolated from Nile perch in Lake Victoria show limited human pathogenic potential
title_fullStr Salmonella Salamae and S. Waycross isolated from Nile perch in Lake Victoria show limited human pathogenic potential
title_full_unstemmed Salmonella Salamae and S. Waycross isolated from Nile perch in Lake Victoria show limited human pathogenic potential
title_short Salmonella Salamae and S. Waycross isolated from Nile perch in Lake Victoria show limited human pathogenic potential
title_sort salmonella salamae and s. waycross isolated from nile perch in lake victoria show limited human pathogenic potential
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913728/
https://www.ncbi.nlm.nih.gov/pubmed/35273308
http://dx.doi.org/10.1038/s41598-022-08200-5
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