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An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway
The sigma-1 receptor (σ(1)R) is a non-opioid transmembrane receptor which has been implicated in many diseases, including neurodegenerative disorders and cancer. After more than forty years of research, substantial progress has been made in understanding this unique receptor, yet the molecular mecha...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913746/ https://www.ncbi.nlm.nih.gov/pubmed/35273182 http://dx.doi.org/10.1038/s41467-022-28946-w |