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Increased Levels of CHI3L1 and HA Are Associated With Higher Occurrence of Liver Damage in Patients With Obstructive Sleep Apnea

BACKGROUND: Obstructive sleep apnea-hypopnea syndrome (OSA) may cause liver fibrosis, and liver fibrosis serum biomarkers plays an important role on the diagnosis of liver fibrosis. In addition, this study aimed to observe the changes of 4 serum markers and Chitinase 3-like protein 1 (CHII3L1) level...

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Autores principales: Cai, Jingyao, Lyu, Xing, Huang, Peiying, Li, Shisheng, Chen, Ruohong, Chen, Zhiyang, Sun, Mei, Zeng, Ling, Wu, Fengxi, Hu, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913888/
https://www.ncbi.nlm.nih.gov/pubmed/35280860
http://dx.doi.org/10.3389/fmed.2022.854570
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author Cai, Jingyao
Lyu, Xing
Huang, Peiying
Li, Shisheng
Chen, Ruohong
Chen, Zhiyang
Sun, Mei
Zeng, Ling
Wu, Fengxi
Hu, Min
author_facet Cai, Jingyao
Lyu, Xing
Huang, Peiying
Li, Shisheng
Chen, Ruohong
Chen, Zhiyang
Sun, Mei
Zeng, Ling
Wu, Fengxi
Hu, Min
author_sort Cai, Jingyao
collection PubMed
description BACKGROUND: Obstructive sleep apnea-hypopnea syndrome (OSA) may cause liver fibrosis, and liver fibrosis serum biomarkers plays an important role on the diagnosis of liver fibrosis. In addition, this study aimed to observe the changes of 4 serum markers and Chitinase 3-like protein 1 (CHII3L1) levels in OSA patients with different disease severity and explore their interactions. And then, we examined whether intermittent hypoxia (IH) exposure can activate hepatic stellate cell. METHODS: 74 OSA patients in Second Xiangya hospital from January 2021 to October 2021 was selected and categorized into mild, moderate, and severe groups according to AHI. In addition, 20 subjects were selected as the control group. Serum levels of liver fibrosis markers were determined by electrochemiluminescence immunoassay. Hepatic stellate cells were exposed to intermittent IH or normoxia (RA). Results were analyzed using the SPSS software. RESULTS: There was a significant increase in serum hyaluronic acid (HA), collagen type IV (CIV) and CHI3L1 levels in OSA patients compared with control group. Specifically, serum liver fibrosis markers HA, CIV and CHI3L1 levels were positively correlated with apnea-hypopnea index (AHI), but negatively correlated with the lowest saturation oxygen (LSaO(2)) respectively. The LX-2 cells (human hepatic stellate cell line) exposed to IH showed significant increases in fibrotic protein expression. CONCLUSION: OSA might either directly or indirectly trigger or exacerbate liver fibrosis, possibly via IH-related pathways.
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spelling pubmed-89138882022-03-12 Increased Levels of CHI3L1 and HA Are Associated With Higher Occurrence of Liver Damage in Patients With Obstructive Sleep Apnea Cai, Jingyao Lyu, Xing Huang, Peiying Li, Shisheng Chen, Ruohong Chen, Zhiyang Sun, Mei Zeng, Ling Wu, Fengxi Hu, Min Front Med (Lausanne) Medicine BACKGROUND: Obstructive sleep apnea-hypopnea syndrome (OSA) may cause liver fibrosis, and liver fibrosis serum biomarkers plays an important role on the diagnosis of liver fibrosis. In addition, this study aimed to observe the changes of 4 serum markers and Chitinase 3-like protein 1 (CHII3L1) levels in OSA patients with different disease severity and explore their interactions. And then, we examined whether intermittent hypoxia (IH) exposure can activate hepatic stellate cell. METHODS: 74 OSA patients in Second Xiangya hospital from January 2021 to October 2021 was selected and categorized into mild, moderate, and severe groups according to AHI. In addition, 20 subjects were selected as the control group. Serum levels of liver fibrosis markers were determined by electrochemiluminescence immunoassay. Hepatic stellate cells were exposed to intermittent IH or normoxia (RA). Results were analyzed using the SPSS software. RESULTS: There was a significant increase in serum hyaluronic acid (HA), collagen type IV (CIV) and CHI3L1 levels in OSA patients compared with control group. Specifically, serum liver fibrosis markers HA, CIV and CHI3L1 levels were positively correlated with apnea-hypopnea index (AHI), but negatively correlated with the lowest saturation oxygen (LSaO(2)) respectively. The LX-2 cells (human hepatic stellate cell line) exposed to IH showed significant increases in fibrotic protein expression. CONCLUSION: OSA might either directly or indirectly trigger or exacerbate liver fibrosis, possibly via IH-related pathways. Frontiers Media S.A. 2022-02-25 /pmc/articles/PMC8913888/ /pubmed/35280860 http://dx.doi.org/10.3389/fmed.2022.854570 Text en Copyright © 2022 Cai, Lyu, Huang, Li, Chen, Chen, Sun, Zeng, Wu and Hu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Cai, Jingyao
Lyu, Xing
Huang, Peiying
Li, Shisheng
Chen, Ruohong
Chen, Zhiyang
Sun, Mei
Zeng, Ling
Wu, Fengxi
Hu, Min
Increased Levels of CHI3L1 and HA Are Associated With Higher Occurrence of Liver Damage in Patients With Obstructive Sleep Apnea
title Increased Levels of CHI3L1 and HA Are Associated With Higher Occurrence of Liver Damage in Patients With Obstructive Sleep Apnea
title_full Increased Levels of CHI3L1 and HA Are Associated With Higher Occurrence of Liver Damage in Patients With Obstructive Sleep Apnea
title_fullStr Increased Levels of CHI3L1 and HA Are Associated With Higher Occurrence of Liver Damage in Patients With Obstructive Sleep Apnea
title_full_unstemmed Increased Levels of CHI3L1 and HA Are Associated With Higher Occurrence of Liver Damage in Patients With Obstructive Sleep Apnea
title_short Increased Levels of CHI3L1 and HA Are Associated With Higher Occurrence of Liver Damage in Patients With Obstructive Sleep Apnea
title_sort increased levels of chi3l1 and ha are associated with higher occurrence of liver damage in patients with obstructive sleep apnea
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913888/
https://www.ncbi.nlm.nih.gov/pubmed/35280860
http://dx.doi.org/10.3389/fmed.2022.854570
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