PTEN Deletion in Adult Mice Induces Hypoinsulinemia With Concomitant Low Glucose Levels

The PI3K/AKT pathway, negatively regulated by PTEN, plays a paramount role in glucose metabolism regulation due to its activation by the insulin receptor signaling pathway. We generated a PTEN-KO mouse to evaluate the systemic effect of the overactivation of the PI3K/AKT pathway in insulin signaling...

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Detalles Bibliográficos
Autores principales: Crespo-Masip, Maria, Pérez-Gómez, Aurora, Guzmán, Carla, Rayego, Sandra, Doladé, Nuria, García-Carrasco, Alicia, Jover, Ramiro, Valdivielso, José Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914015/
https://www.ncbi.nlm.nih.gov/pubmed/35282439
http://dx.doi.org/10.3389/fendo.2022.850214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914015/
https://www.ncbi.nlm.nih.gov/pubmed/35282439
http://dx.doi.org/10.3389/fendo.2022.850214

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