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Weighing in on Adipogenesis
Obesity is a growing health concern worldwide because of its contribution to metabolic syndrome, type II diabetes, insulin resistance (IR), and numerous cancers. In obesity, white adipose tissue (WAT) expands through two mechanisms: increase in adipocyte cell number by precursor cell differentiation...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914022/ https://www.ncbi.nlm.nih.gov/pubmed/35283790 http://dx.doi.org/10.3389/fphys.2022.821278 |
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author | Nunn, Elizabeth R. Shinde, Abhijit B. Zaganjor, Elma |
author_facet | Nunn, Elizabeth R. Shinde, Abhijit B. Zaganjor, Elma |
author_sort | Nunn, Elizabeth R. |
collection | PubMed |
description | Obesity is a growing health concern worldwide because of its contribution to metabolic syndrome, type II diabetes, insulin resistance (IR), and numerous cancers. In obesity, white adipose tissue (WAT) expands through two mechanisms: increase in adipocyte cell number by precursor cell differentiation through the process of adipogenesis (hyperplasia) and increase in existing mature adipocyte cell size (hypertrophy). While hypertrophy is associated with the negative effects of obesity on metabolic health, such as inflammation and lipotoxicity, adipogenesis prevents obesity-mediated metabolic decline. Moreover, in metabolically healthy obesity adipogenesis is increased. Thus, it is vital to understand the mechanistic basis for adipose expansion to inform novel therapeutic approaches to mitigate the dysfunction of this tissue and associated diseases. In this mini-review, we summarize recent studies on the regulation of adipogenesis and provide a perspective on targeting adipogenesis as a potential therapeutic avenue for metabolic disorders. |
format | Online Article Text |
id | pubmed-8914022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89140222022-03-12 Weighing in on Adipogenesis Nunn, Elizabeth R. Shinde, Abhijit B. Zaganjor, Elma Front Physiol Physiology Obesity is a growing health concern worldwide because of its contribution to metabolic syndrome, type II diabetes, insulin resistance (IR), and numerous cancers. In obesity, white adipose tissue (WAT) expands through two mechanisms: increase in adipocyte cell number by precursor cell differentiation through the process of adipogenesis (hyperplasia) and increase in existing mature adipocyte cell size (hypertrophy). While hypertrophy is associated with the negative effects of obesity on metabolic health, such as inflammation and lipotoxicity, adipogenesis prevents obesity-mediated metabolic decline. Moreover, in metabolically healthy obesity adipogenesis is increased. Thus, it is vital to understand the mechanistic basis for adipose expansion to inform novel therapeutic approaches to mitigate the dysfunction of this tissue and associated diseases. In this mini-review, we summarize recent studies on the regulation of adipogenesis and provide a perspective on targeting adipogenesis as a potential therapeutic avenue for metabolic disorders. Frontiers Media S.A. 2022-02-25 /pmc/articles/PMC8914022/ /pubmed/35283790 http://dx.doi.org/10.3389/fphys.2022.821278 Text en Copyright © 2022 Nunn, Shinde and Zaganjor. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Nunn, Elizabeth R. Shinde, Abhijit B. Zaganjor, Elma Weighing in on Adipogenesis |
title | Weighing in on Adipogenesis |
title_full | Weighing in on Adipogenesis |
title_fullStr | Weighing in on Adipogenesis |
title_full_unstemmed | Weighing in on Adipogenesis |
title_short | Weighing in on Adipogenesis |
title_sort | weighing in on adipogenesis |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914022/ https://www.ncbi.nlm.nih.gov/pubmed/35283790 http://dx.doi.org/10.3389/fphys.2022.821278 |
work_keys_str_mv | AT nunnelizabethr weighinginonadipogenesis AT shindeabhijitb weighinginonadipogenesis AT zaganjorelma weighinginonadipogenesis |