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Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway
The type-I interferon (IFN-I) signaling pathway plays pivot roles in defending against pathogen invasion. Exogenous ssRNA and dsRNA could be immunogenic. RNA-mediated IFN signaling is extensively studied in the field. The incorrect functioning of this pathway leads to either autoimmune diseases or s...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914027/ https://www.ncbi.nlm.nih.gov/pubmed/35280983 http://dx.doi.org/10.3389/fimmu.2022.811122 |
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author | Ji, Xiaoxin Meng, Wei Liu, Zichuan Mu, Xin |
author_facet | Ji, Xiaoxin Meng, Wei Liu, Zichuan Mu, Xin |
author_sort | Ji, Xiaoxin |
collection | PubMed |
description | The type-I interferon (IFN-I) signaling pathway plays pivot roles in defending against pathogen invasion. Exogenous ssRNA and dsRNA could be immunogenic. RNA-mediated IFN signaling is extensively studied in the field. The incorrect functioning of this pathway leads to either autoimmune diseases or suffering from microorganism invasion. From the discrimination of “self” and “non-self” molecules by receptors to the fine-tune modulations in downstream cascades, all steps are under the surveillance featured by complex feedbacks and regulators. Studies in recent years highlighted the emerging roles of long noncoding RNAs (lncRNAs) as a reservoir for signaling regulation. LncRNAs bind to targets through the structure and sequence, and thus the mechanisms of action can be complex and specific. Here, we summarized lncRNAs modulating the RNA-activated IFN-I signaling pathway according to the event order during the signaling. We hope this review help understand how lncRNAs are participating in the regulation of IFN-I signaling. |
format | Online Article Text |
id | pubmed-8914027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89140272022-03-12 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway Ji, Xiaoxin Meng, Wei Liu, Zichuan Mu, Xin Front Immunol Immunology The type-I interferon (IFN-I) signaling pathway plays pivot roles in defending against pathogen invasion. Exogenous ssRNA and dsRNA could be immunogenic. RNA-mediated IFN signaling is extensively studied in the field. The incorrect functioning of this pathway leads to either autoimmune diseases or suffering from microorganism invasion. From the discrimination of “self” and “non-self” molecules by receptors to the fine-tune modulations in downstream cascades, all steps are under the surveillance featured by complex feedbacks and regulators. Studies in recent years highlighted the emerging roles of long noncoding RNAs (lncRNAs) as a reservoir for signaling regulation. LncRNAs bind to targets through the structure and sequence, and thus the mechanisms of action can be complex and specific. Here, we summarized lncRNAs modulating the RNA-activated IFN-I signaling pathway according to the event order during the signaling. We hope this review help understand how lncRNAs are participating in the regulation of IFN-I signaling. Frontiers Media S.A. 2022-02-25 /pmc/articles/PMC8914027/ /pubmed/35280983 http://dx.doi.org/10.3389/fimmu.2022.811122 Text en Copyright © 2022 Ji, Meng, Liu and Mu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Ji, Xiaoxin Meng, Wei Liu, Zichuan Mu, Xin Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway |
title | Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway |
title_full | Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway |
title_fullStr | Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway |
title_full_unstemmed | Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway |
title_short | Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway |
title_sort | emerging roles of lncrnas regulating rna-mediated type-i interferon signaling pathway |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914027/ https://www.ncbi.nlm.nih.gov/pubmed/35280983 http://dx.doi.org/10.3389/fimmu.2022.811122 |
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