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Epigenetic Transgenerational Modifications Induced by Xenobiotic Exposure in Zebrafish

Zebrafish (Danio rerio) is a well-established vertebrate model in ecotoxicology research that responds to a wide range of xenobiotics such as pesticides, drugs, and endocrine-disrupting compounds. The epigenome can interact with the environment and transform internal and/or external signals into phe...

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Autores principales: Terrazas-Salgado, Luis, García-Gasca, Alejandra, Betancourt-Lozano, Miguel, Llera-Herrera, Raúl, Alvarado-Cruz, Isabel, Yáñez-Rivera, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914061/
https://www.ncbi.nlm.nih.gov/pubmed/35281093
http://dx.doi.org/10.3389/fcell.2022.832982
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author Terrazas-Salgado, Luis
García-Gasca, Alejandra
Betancourt-Lozano, Miguel
Llera-Herrera, Raúl
Alvarado-Cruz, Isabel
Yáñez-Rivera, Beatriz
author_facet Terrazas-Salgado, Luis
García-Gasca, Alejandra
Betancourt-Lozano, Miguel
Llera-Herrera, Raúl
Alvarado-Cruz, Isabel
Yáñez-Rivera, Beatriz
author_sort Terrazas-Salgado, Luis
collection PubMed
description Zebrafish (Danio rerio) is a well-established vertebrate model in ecotoxicology research that responds to a wide range of xenobiotics such as pesticides, drugs, and endocrine-disrupting compounds. The epigenome can interact with the environment and transform internal and/or external signals into phenotypic responses through changes in gene transcription. Environmental exposures can also generate epigenetic variations in offspring even by indirect exposure. In this review, we address the advantages of using zebrafish as an experimental animal model to study transgenerational epigenetic processes upon exposure to xenobiotics. We focused mostly on DNA methylation, although studies on post-translational modifications of histones, and non-coding RNAs related to xenobiotic exposure in zebrafish are also discussed. A revision of the methods used to study epigenetic changes in zebrafish revealed the relevance and reproducibility for epigenetics-related research. PubMed and Google Scholar databases were consulted for original research articles published from 2013 to date, by using six keywords: zebrafish, epigenetics, exposure, parental, transgenerational, and F2. From 499 articles identified, 92 were considered, of which 14 were selected as included F2 and epigenetic mechanisms. Current knowledge regarding the effect of xenobiotics on DNA methylation, histone modifications, and changes in non-coding RNAs expressed in F2 is summarized, along with key experimental design considerations to characterize transgenerational effects.
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spelling pubmed-89140612022-03-12 Epigenetic Transgenerational Modifications Induced by Xenobiotic Exposure in Zebrafish Terrazas-Salgado, Luis García-Gasca, Alejandra Betancourt-Lozano, Miguel Llera-Herrera, Raúl Alvarado-Cruz, Isabel Yáñez-Rivera, Beatriz Front Cell Dev Biol Cell and Developmental Biology Zebrafish (Danio rerio) is a well-established vertebrate model in ecotoxicology research that responds to a wide range of xenobiotics such as pesticides, drugs, and endocrine-disrupting compounds. The epigenome can interact with the environment and transform internal and/or external signals into phenotypic responses through changes in gene transcription. Environmental exposures can also generate epigenetic variations in offspring even by indirect exposure. In this review, we address the advantages of using zebrafish as an experimental animal model to study transgenerational epigenetic processes upon exposure to xenobiotics. We focused mostly on DNA methylation, although studies on post-translational modifications of histones, and non-coding RNAs related to xenobiotic exposure in zebrafish are also discussed. A revision of the methods used to study epigenetic changes in zebrafish revealed the relevance and reproducibility for epigenetics-related research. PubMed and Google Scholar databases were consulted for original research articles published from 2013 to date, by using six keywords: zebrafish, epigenetics, exposure, parental, transgenerational, and F2. From 499 articles identified, 92 were considered, of which 14 were selected as included F2 and epigenetic mechanisms. Current knowledge regarding the effect of xenobiotics on DNA methylation, histone modifications, and changes in non-coding RNAs expressed in F2 is summarized, along with key experimental design considerations to characterize transgenerational effects. Frontiers Media S.A. 2022-02-25 /pmc/articles/PMC8914061/ /pubmed/35281093 http://dx.doi.org/10.3389/fcell.2022.832982 Text en Copyright © 2022 Terrazas-Salgado, García-Gasca, Betancourt-Lozano, Llera-Herrera, Alvarado-Cruz and Yáñez-Rivera. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Terrazas-Salgado, Luis
García-Gasca, Alejandra
Betancourt-Lozano, Miguel
Llera-Herrera, Raúl
Alvarado-Cruz, Isabel
Yáñez-Rivera, Beatriz
Epigenetic Transgenerational Modifications Induced by Xenobiotic Exposure in Zebrafish
title Epigenetic Transgenerational Modifications Induced by Xenobiotic Exposure in Zebrafish
title_full Epigenetic Transgenerational Modifications Induced by Xenobiotic Exposure in Zebrafish
title_fullStr Epigenetic Transgenerational Modifications Induced by Xenobiotic Exposure in Zebrafish
title_full_unstemmed Epigenetic Transgenerational Modifications Induced by Xenobiotic Exposure in Zebrafish
title_short Epigenetic Transgenerational Modifications Induced by Xenobiotic Exposure in Zebrafish
title_sort epigenetic transgenerational modifications induced by xenobiotic exposure in zebrafish
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914061/
https://www.ncbi.nlm.nih.gov/pubmed/35281093
http://dx.doi.org/10.3389/fcell.2022.832982
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