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Temporal Progression Patterns of Brain Atrophy in Corticobasal Syndrome and Progressive Supranuclear Palsy Revealed by Subtype and Stage Inference (SuStaIn)

Differentiating corticobasal degeneration presenting with corticobasal syndrome (CBD-CBS) from progressive supranuclear palsy with Richardson's syndrome (PSP-RS), particularly in early stages, is often challenging because the neurodegenerative conditions closely overlap in terms of clinical pre...

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Autores principales: Saito, Yuya, Kamagata, Koji, Wijeratne, Peter A., Andica, Christina, Uchida, Wataru, Takabayashi, Kaito, Fujita, Shohei, Akashi, Toshiaki, Wada, Akihiko, Shimoji, Keigo, Hori, Masaaki, Masutani, Yoshitaka, Alexander, Daniel C., Aoki, Shigeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914081/
https://www.ncbi.nlm.nih.gov/pubmed/35280291
http://dx.doi.org/10.3389/fneur.2022.814768
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author Saito, Yuya
Kamagata, Koji
Wijeratne, Peter A.
Andica, Christina
Uchida, Wataru
Takabayashi, Kaito
Fujita, Shohei
Akashi, Toshiaki
Wada, Akihiko
Shimoji, Keigo
Hori, Masaaki
Masutani, Yoshitaka
Alexander, Daniel C.
Aoki, Shigeki
author_facet Saito, Yuya
Kamagata, Koji
Wijeratne, Peter A.
Andica, Christina
Uchida, Wataru
Takabayashi, Kaito
Fujita, Shohei
Akashi, Toshiaki
Wada, Akihiko
Shimoji, Keigo
Hori, Masaaki
Masutani, Yoshitaka
Alexander, Daniel C.
Aoki, Shigeki
author_sort Saito, Yuya
collection PubMed
description Differentiating corticobasal degeneration presenting with corticobasal syndrome (CBD-CBS) from progressive supranuclear palsy with Richardson's syndrome (PSP-RS), particularly in early stages, is often challenging because the neurodegenerative conditions closely overlap in terms of clinical presentation and pathology. Although volumetry using brain magnetic resonance imaging (MRI) has been studied in patients with CBS and PSP-RS, studies assessing the progression of brain atrophy are limited. Therefore, we aimed to reveal the difference in the temporal progression patterns of brain atrophy between patients with CBS and those with PSP-RS purely based on cross-sectional data using Subtype and Stage Inference (SuStaIn)—a novel, unsupervised machine learning technique that integrates clustering and disease progression modeling. We applied SuStaIn to the cross-sectional regional brain volumes of 25 patients with CBS, 39 patients with typical PSP-RS, and 50 healthy controls to estimate the two disease subtypes and trajectories of CBS and PSP-RS, which have distinct atrophy patterns. The progression model and classification accuracy of CBS and PSP-RS were compared with those of previous studies to evaluate the performance of SuStaIn. SuStaIn identified distinct temporal progression patterns of brain atrophy for CBS and PSP-RS, which were largely consistent with previous evidence, with high reproducibility (99.7%) under cross-validation. We classified these diseases with high accuracy (0.875) and sensitivity (0.680 and 1.000, respectively) based on cross-sectional structural brain MRI data; the accuracy was higher than that reported in previous studies. Moreover, SuStaIn stage correctly reflected disease severity without the label of disease stage, such as disease duration. Furthermore, SuStaIn also showed the genialized performance of differentiation and reflection for CBS and PSP-RS. Thus, SuStaIn has potential for improving our understanding of disease mechanisms, accurately stratifying patients, and providing prognoses for patients with CBS and PSP-RS.
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spelling pubmed-89140812022-03-12 Temporal Progression Patterns of Brain Atrophy in Corticobasal Syndrome and Progressive Supranuclear Palsy Revealed by Subtype and Stage Inference (SuStaIn) Saito, Yuya Kamagata, Koji Wijeratne, Peter A. Andica, Christina Uchida, Wataru Takabayashi, Kaito Fujita, Shohei Akashi, Toshiaki Wada, Akihiko Shimoji, Keigo Hori, Masaaki Masutani, Yoshitaka Alexander, Daniel C. Aoki, Shigeki Front Neurol Neurology Differentiating corticobasal degeneration presenting with corticobasal syndrome (CBD-CBS) from progressive supranuclear palsy with Richardson's syndrome (PSP-RS), particularly in early stages, is often challenging because the neurodegenerative conditions closely overlap in terms of clinical presentation and pathology. Although volumetry using brain magnetic resonance imaging (MRI) has been studied in patients with CBS and PSP-RS, studies assessing the progression of brain atrophy are limited. Therefore, we aimed to reveal the difference in the temporal progression patterns of brain atrophy between patients with CBS and those with PSP-RS purely based on cross-sectional data using Subtype and Stage Inference (SuStaIn)—a novel, unsupervised machine learning technique that integrates clustering and disease progression modeling. We applied SuStaIn to the cross-sectional regional brain volumes of 25 patients with CBS, 39 patients with typical PSP-RS, and 50 healthy controls to estimate the two disease subtypes and trajectories of CBS and PSP-RS, which have distinct atrophy patterns. The progression model and classification accuracy of CBS and PSP-RS were compared with those of previous studies to evaluate the performance of SuStaIn. SuStaIn identified distinct temporal progression patterns of brain atrophy for CBS and PSP-RS, which were largely consistent with previous evidence, with high reproducibility (99.7%) under cross-validation. We classified these diseases with high accuracy (0.875) and sensitivity (0.680 and 1.000, respectively) based on cross-sectional structural brain MRI data; the accuracy was higher than that reported in previous studies. Moreover, SuStaIn stage correctly reflected disease severity without the label of disease stage, such as disease duration. Furthermore, SuStaIn also showed the genialized performance of differentiation and reflection for CBS and PSP-RS. Thus, SuStaIn has potential for improving our understanding of disease mechanisms, accurately stratifying patients, and providing prognoses for patients with CBS and PSP-RS. Frontiers Media S.A. 2022-02-25 /pmc/articles/PMC8914081/ /pubmed/35280291 http://dx.doi.org/10.3389/fneur.2022.814768 Text en Copyright © 2022 Saito, Kamagata, Wijeratne, Andica, Uchida, Takabayashi, Fujita, Akashi, Wada, Shimoji, Hori, Masutani, Alexander and Aoki. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Saito, Yuya
Kamagata, Koji
Wijeratne, Peter A.
Andica, Christina
Uchida, Wataru
Takabayashi, Kaito
Fujita, Shohei
Akashi, Toshiaki
Wada, Akihiko
Shimoji, Keigo
Hori, Masaaki
Masutani, Yoshitaka
Alexander, Daniel C.
Aoki, Shigeki
Temporal Progression Patterns of Brain Atrophy in Corticobasal Syndrome and Progressive Supranuclear Palsy Revealed by Subtype and Stage Inference (SuStaIn)
title Temporal Progression Patterns of Brain Atrophy in Corticobasal Syndrome and Progressive Supranuclear Palsy Revealed by Subtype and Stage Inference (SuStaIn)
title_full Temporal Progression Patterns of Brain Atrophy in Corticobasal Syndrome and Progressive Supranuclear Palsy Revealed by Subtype and Stage Inference (SuStaIn)
title_fullStr Temporal Progression Patterns of Brain Atrophy in Corticobasal Syndrome and Progressive Supranuclear Palsy Revealed by Subtype and Stage Inference (SuStaIn)
title_full_unstemmed Temporal Progression Patterns of Brain Atrophy in Corticobasal Syndrome and Progressive Supranuclear Palsy Revealed by Subtype and Stage Inference (SuStaIn)
title_short Temporal Progression Patterns of Brain Atrophy in Corticobasal Syndrome and Progressive Supranuclear Palsy Revealed by Subtype and Stage Inference (SuStaIn)
title_sort temporal progression patterns of brain atrophy in corticobasal syndrome and progressive supranuclear palsy revealed by subtype and stage inference (sustain)
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914081/
https://www.ncbi.nlm.nih.gov/pubmed/35280291
http://dx.doi.org/10.3389/fneur.2022.814768
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