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Prognostic Value of Sarcopenia in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP: A Systematic Review and Meta-Analysis

OBJECTIVE: Several studies have reported conflicting results regarding the association between sarcopenia and outcomes in patients with diffuse large B-cell lymphoma (DLBCL). This meta-analysis aimed to evaluate the prognostic value of sarcopenia in patients with DLBCL. METHODS: PubMed, Embase, and...

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Autores principales: Xu, Xin-Tian, He, Dong-Liang, Tian, Meng-Xing, Wu, Hui-Jing, Jin, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914205/
https://www.ncbi.nlm.nih.gov/pubmed/35284466
http://dx.doi.org/10.3389/fnut.2022.816883
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author Xu, Xin-Tian
He, Dong-Liang
Tian, Meng-Xing
Wu, Hui-Jing
Jin, Xin
author_facet Xu, Xin-Tian
He, Dong-Liang
Tian, Meng-Xing
Wu, Hui-Jing
Jin, Xin
author_sort Xu, Xin-Tian
collection PubMed
description OBJECTIVE: Several studies have reported conflicting results regarding the association between sarcopenia and outcomes in patients with diffuse large B-cell lymphoma (DLBCL). This meta-analysis aimed to evaluate the prognostic value of sarcopenia in patients with DLBCL. METHODS: PubMed, Embase, and Cochrane Library databases were searched to identify trials exploring the association between sarcopenia and prognosis in patients with DLBCL treated with chemotherapy. A meta-analysis of overall survival (OS), progression-free survival (PFS), treatment completion, and rate of complete response (CR) was performed. RESULTS: Twelve studies that involved 2,324 patients with DLBCL were included. Sarcopenia was associated with poor OS and PFS in patients with DLBCL, even after adjusting for confounders. Patients with sarcopenia had lower rates of CR and treatment completion than patients without sarcopenia. CONCLUSIONS: Sarcopenia is a negative predictor of prognosis in patients with DLBCL. Additional and prospective studies investigating the diagnostic criteria for sarcopenia are warranted.
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spelling pubmed-89142052022-03-12 Prognostic Value of Sarcopenia in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP: A Systematic Review and Meta-Analysis Xu, Xin-Tian He, Dong-Liang Tian, Meng-Xing Wu, Hui-Jing Jin, Xin Front Nutr Nutrition OBJECTIVE: Several studies have reported conflicting results regarding the association between sarcopenia and outcomes in patients with diffuse large B-cell lymphoma (DLBCL). This meta-analysis aimed to evaluate the prognostic value of sarcopenia in patients with DLBCL. METHODS: PubMed, Embase, and Cochrane Library databases were searched to identify trials exploring the association between sarcopenia and prognosis in patients with DLBCL treated with chemotherapy. A meta-analysis of overall survival (OS), progression-free survival (PFS), treatment completion, and rate of complete response (CR) was performed. RESULTS: Twelve studies that involved 2,324 patients with DLBCL were included. Sarcopenia was associated with poor OS and PFS in patients with DLBCL, even after adjusting for confounders. Patients with sarcopenia had lower rates of CR and treatment completion than patients without sarcopenia. CONCLUSIONS: Sarcopenia is a negative predictor of prognosis in patients with DLBCL. Additional and prospective studies investigating the diagnostic criteria for sarcopenia are warranted. Frontiers Media S.A. 2022-02-25 /pmc/articles/PMC8914205/ /pubmed/35284466 http://dx.doi.org/10.3389/fnut.2022.816883 Text en Copyright © 2022 Xu, He, Tian, Wu and Jin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Xu, Xin-Tian
He, Dong-Liang
Tian, Meng-Xing
Wu, Hui-Jing
Jin, Xin
Prognostic Value of Sarcopenia in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP: A Systematic Review and Meta-Analysis
title Prognostic Value of Sarcopenia in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP: A Systematic Review and Meta-Analysis
title_full Prognostic Value of Sarcopenia in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP: A Systematic Review and Meta-Analysis
title_fullStr Prognostic Value of Sarcopenia in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP: A Systematic Review and Meta-Analysis
title_full_unstemmed Prognostic Value of Sarcopenia in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP: A Systematic Review and Meta-Analysis
title_short Prognostic Value of Sarcopenia in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP: A Systematic Review and Meta-Analysis
title_sort prognostic value of sarcopenia in patients with diffuse large b-cell lymphoma treated with r-chop: a systematic review and meta-analysis
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914205/
https://www.ncbi.nlm.nih.gov/pubmed/35284466
http://dx.doi.org/10.3389/fnut.2022.816883
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