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Alterations to the gut microbiome after sport-related concussion in a collegiate football players cohort: A pilot study

Concussions, both single and repetitive, cause brain and body alterations in athletes during contact sports. The role of the brain-gut connection and changes in the microbiota have not been well established after sports-related concussions or repetitive subconcussive impacts. We recruited 33 Divisio...

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Autores principales: Soriano, Sirena, Curry, Kristen, Sadrameli, Saeed S., Wang, Qi, Nute, Michael, Reeves, Elizabeth, Kabir, Rasadul, Wiese, Jonathan, Criswell, Amber, Schodrof, Sarah, Britz, Gavin W., Gadhia, Rajan, Podell, Kenneth, Treangen, Todd, Villapol, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914332/
https://www.ncbi.nlm.nih.gov/pubmed/35284846
http://dx.doi.org/10.1016/j.bbih.2022.100438
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author Soriano, Sirena
Curry, Kristen
Sadrameli, Saeed S.
Wang, Qi
Nute, Michael
Reeves, Elizabeth
Kabir, Rasadul
Wiese, Jonathan
Criswell, Amber
Schodrof, Sarah
Britz, Gavin W.
Gadhia, Rajan
Podell, Kenneth
Treangen, Todd
Villapol, Sonia
author_facet Soriano, Sirena
Curry, Kristen
Sadrameli, Saeed S.
Wang, Qi
Nute, Michael
Reeves, Elizabeth
Kabir, Rasadul
Wiese, Jonathan
Criswell, Amber
Schodrof, Sarah
Britz, Gavin W.
Gadhia, Rajan
Podell, Kenneth
Treangen, Todd
Villapol, Sonia
author_sort Soriano, Sirena
collection PubMed
description Concussions, both single and repetitive, cause brain and body alterations in athletes during contact sports. The role of the brain-gut connection and changes in the microbiota have not been well established after sports-related concussions or repetitive subconcussive impacts. We recruited 33 Division I Collegiate football players and collected blood, stool, and saliva samples at three time points throughout the athletic season: mid-season, following the last competitive game (post-season), and after a resting period in the off-season. Additional samples were collected from four athletes that suffered from a concussion. 16S rRNA sequencing of the gut microbiome revealed a decrease in abundance for two bacterial species, Eubacterium rectale, and Anaerostipes hadrus, after a diagnosed concussion. No significant differences were found regarding the salivary microbiome. Serum biomarker analysis shows an increase in GFAP blood levels in athletes during the competitive season. Additionally, S100β and SAA blood levels were positively correlated with the abundance of Eubacterium rectale species among the group of athletes that did not suffer a diagnosed concussion during the sports season. These findings provide initial evidence that detecting changes in the gut microbiome may help to improve concussion diagnosis following head injury.
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spelling pubmed-89143322022-03-12 Alterations to the gut microbiome after sport-related concussion in a collegiate football players cohort: A pilot study Soriano, Sirena Curry, Kristen Sadrameli, Saeed S. Wang, Qi Nute, Michael Reeves, Elizabeth Kabir, Rasadul Wiese, Jonathan Criswell, Amber Schodrof, Sarah Britz, Gavin W. Gadhia, Rajan Podell, Kenneth Treangen, Todd Villapol, Sonia Brain Behav Immun Health Full Length Article Concussions, both single and repetitive, cause brain and body alterations in athletes during contact sports. The role of the brain-gut connection and changes in the microbiota have not been well established after sports-related concussions or repetitive subconcussive impacts. We recruited 33 Division I Collegiate football players and collected blood, stool, and saliva samples at three time points throughout the athletic season: mid-season, following the last competitive game (post-season), and after a resting period in the off-season. Additional samples were collected from four athletes that suffered from a concussion. 16S rRNA sequencing of the gut microbiome revealed a decrease in abundance for two bacterial species, Eubacterium rectale, and Anaerostipes hadrus, after a diagnosed concussion. No significant differences were found regarding the salivary microbiome. Serum biomarker analysis shows an increase in GFAP blood levels in athletes during the competitive season. Additionally, S100β and SAA blood levels were positively correlated with the abundance of Eubacterium rectale species among the group of athletes that did not suffer a diagnosed concussion during the sports season. These findings provide initial evidence that detecting changes in the gut microbiome may help to improve concussion diagnosis following head injury. Elsevier 2022-03-01 /pmc/articles/PMC8914332/ /pubmed/35284846 http://dx.doi.org/10.1016/j.bbih.2022.100438 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Full Length Article
Soriano, Sirena
Curry, Kristen
Sadrameli, Saeed S.
Wang, Qi
Nute, Michael
Reeves, Elizabeth
Kabir, Rasadul
Wiese, Jonathan
Criswell, Amber
Schodrof, Sarah
Britz, Gavin W.
Gadhia, Rajan
Podell, Kenneth
Treangen, Todd
Villapol, Sonia
Alterations to the gut microbiome after sport-related concussion in a collegiate football players cohort: A pilot study
title Alterations to the gut microbiome after sport-related concussion in a collegiate football players cohort: A pilot study
title_full Alterations to the gut microbiome after sport-related concussion in a collegiate football players cohort: A pilot study
title_fullStr Alterations to the gut microbiome after sport-related concussion in a collegiate football players cohort: A pilot study
title_full_unstemmed Alterations to the gut microbiome after sport-related concussion in a collegiate football players cohort: A pilot study
title_short Alterations to the gut microbiome after sport-related concussion in a collegiate football players cohort: A pilot study
title_sort alterations to the gut microbiome after sport-related concussion in a collegiate football players cohort: a pilot study
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914332/
https://www.ncbi.nlm.nih.gov/pubmed/35284846
http://dx.doi.org/10.1016/j.bbih.2022.100438
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