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Emerging Roles and Mechanisms of lncRNA FOXD3-AS1 in Human Diseases

Numerous long noncoding RNAs (lncRNAs) have been identified as powerful regulators of human diseases. The lncRNA FOXD3-AS1 is a novel lncRNA that was recently shown to exert imperative roles in the initialization and progression of several diseases. Emerging studies have shown aberrant expression of...

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Detalles Bibliográficos
Autores principales: Yao, Qinfan, Zhang, Xiuyuan, Chen, Dajin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914342/
https://www.ncbi.nlm.nih.gov/pubmed/35280790
http://dx.doi.org/10.3389/fonc.2022.848296
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author Yao, Qinfan
Zhang, Xiuyuan
Chen, Dajin
author_facet Yao, Qinfan
Zhang, Xiuyuan
Chen, Dajin
author_sort Yao, Qinfan
collection PubMed
description Numerous long noncoding RNAs (lncRNAs) have been identified as powerful regulators of human diseases. The lncRNA FOXD3-AS1 is a novel lncRNA that was recently shown to exert imperative roles in the initialization and progression of several diseases. Emerging studies have shown aberrant expression of FOXD3-AS1 and close correlation with pathophysiological traits of numerous diseases, particularly cancers. More importantly, FOXD3-AS1 was also found to ubiquitously impact a range of biological functions. This study aims to summarize the expression, associated clinicopathological features, major functions and molecular mechanisms of FOXD3-AS1 in human diseases and to explore its possible clinical applications.
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spelling pubmed-89143422022-03-12 Emerging Roles and Mechanisms of lncRNA FOXD3-AS1 in Human Diseases Yao, Qinfan Zhang, Xiuyuan Chen, Dajin Front Oncol Oncology Numerous long noncoding RNAs (lncRNAs) have been identified as powerful regulators of human diseases. The lncRNA FOXD3-AS1 is a novel lncRNA that was recently shown to exert imperative roles in the initialization and progression of several diseases. Emerging studies have shown aberrant expression of FOXD3-AS1 and close correlation with pathophysiological traits of numerous diseases, particularly cancers. More importantly, FOXD3-AS1 was also found to ubiquitously impact a range of biological functions. This study aims to summarize the expression, associated clinicopathological features, major functions and molecular mechanisms of FOXD3-AS1 in human diseases and to explore its possible clinical applications. Frontiers Media S.A. 2022-02-25 /pmc/articles/PMC8914342/ /pubmed/35280790 http://dx.doi.org/10.3389/fonc.2022.848296 Text en Copyright © 2022 Yao, Zhang and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yao, Qinfan
Zhang, Xiuyuan
Chen, Dajin
Emerging Roles and Mechanisms of lncRNA FOXD3-AS1 in Human Diseases
title Emerging Roles and Mechanisms of lncRNA FOXD3-AS1 in Human Diseases
title_full Emerging Roles and Mechanisms of lncRNA FOXD3-AS1 in Human Diseases
title_fullStr Emerging Roles and Mechanisms of lncRNA FOXD3-AS1 in Human Diseases
title_full_unstemmed Emerging Roles and Mechanisms of lncRNA FOXD3-AS1 in Human Diseases
title_short Emerging Roles and Mechanisms of lncRNA FOXD3-AS1 in Human Diseases
title_sort emerging roles and mechanisms of lncrna foxd3-as1 in human diseases
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914342/
https://www.ncbi.nlm.nih.gov/pubmed/35280790
http://dx.doi.org/10.3389/fonc.2022.848296
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