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The promiscuous and highly mobile resistome of Acinetobacter baumannii

Antimicrobial resistance (AR) is a major global threat to public health. Understanding the population dynamics of AR is critical to restrain and control this issue. However, no study has provided a global picture of the whole resistome of Acinetobacter baumannii , a very important nosocomial pathoge...

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Autores principales: Hernández-González, Ismael L, Mateo-Estrada, Valeria, Castillo-Ramirez, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914355/
https://www.ncbi.nlm.nih.gov/pubmed/35075990
http://dx.doi.org/10.1099/mgen.0.000762
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author Hernández-González, Ismael L
Mateo-Estrada, Valeria
Castillo-Ramirez, Santiago
author_facet Hernández-González, Ismael L
Mateo-Estrada, Valeria
Castillo-Ramirez, Santiago
author_sort Hernández-González, Ismael L
collection PubMed
description Antimicrobial resistance (AR) is a major global threat to public health. Understanding the population dynamics of AR is critical to restrain and control this issue. However, no study has provided a global picture of the whole resistome of Acinetobacter baumannii , a very important nosocomial pathogen. Here we analyse 1450+ genomes (covering >40 countries and >4 decades) to infer the global population dynamics of the resistome of this species. We show that gene flow and horizontal transfer have driven the dissemination of AR genes in A. baumannii . We found considerable variation in AR gene content across lineages. Although the individual AR gene histories have been affected by recombination, the AR gene content has been shaped by the phylogeny. Furthermore, many AR genes have been transferred to other well-known pathogens, such as Pseudomonas aeruginosa or Klebsiella pneumoniae . Despite using this massive data set, we were not able to sample the whole diversity of AR genes, which suggests that this species has an open resistome. Our results highlight the high mobilization risk of AR genes between important pathogens. On a broader perspective, this study gives a framework for an emerging perspective (resistome-centric) on the genomic epidemiology (and surveillance) of bacterial pathogens.
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spelling pubmed-89143552022-03-11 The promiscuous and highly mobile resistome of Acinetobacter baumannii Hernández-González, Ismael L Mateo-Estrada, Valeria Castillo-Ramirez, Santiago Microb Genom Research Articles Antimicrobial resistance (AR) is a major global threat to public health. Understanding the population dynamics of AR is critical to restrain and control this issue. However, no study has provided a global picture of the whole resistome of Acinetobacter baumannii , a very important nosocomial pathogen. Here we analyse 1450+ genomes (covering >40 countries and >4 decades) to infer the global population dynamics of the resistome of this species. We show that gene flow and horizontal transfer have driven the dissemination of AR genes in A. baumannii . We found considerable variation in AR gene content across lineages. Although the individual AR gene histories have been affected by recombination, the AR gene content has been shaped by the phylogeny. Furthermore, many AR genes have been transferred to other well-known pathogens, such as Pseudomonas aeruginosa or Klebsiella pneumoniae . Despite using this massive data set, we were not able to sample the whole diversity of AR genes, which suggests that this species has an open resistome. Our results highlight the high mobilization risk of AR genes between important pathogens. On a broader perspective, this study gives a framework for an emerging perspective (resistome-centric) on the genomic epidemiology (and surveillance) of bacterial pathogens. Microbiology Society 2022-01-25 /pmc/articles/PMC8914355/ /pubmed/35075990 http://dx.doi.org/10.1099/mgen.0.000762 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Articles
Hernández-González, Ismael L
Mateo-Estrada, Valeria
Castillo-Ramirez, Santiago
The promiscuous and highly mobile resistome of Acinetobacter baumannii
title The promiscuous and highly mobile resistome of Acinetobacter baumannii
title_full The promiscuous and highly mobile resistome of Acinetobacter baumannii
title_fullStr The promiscuous and highly mobile resistome of Acinetobacter baumannii
title_full_unstemmed The promiscuous and highly mobile resistome of Acinetobacter baumannii
title_short The promiscuous and highly mobile resistome of Acinetobacter baumannii
title_sort promiscuous and highly mobile resistome of acinetobacter baumannii
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914355/
https://www.ncbi.nlm.nih.gov/pubmed/35075990
http://dx.doi.org/10.1099/mgen.0.000762
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