Cargando…

Continuous Glucose Monitoring in Adolescents With Obesity: Monitoring of Glucose Profiles, Glycemic Excursions, and Adherence to Time Restricted Eating Programs

BACKGROUND: Randomized controlled trials of time restricted eating (TRE) in adults have demonstrated improvements in glucose variability as captured by continuous glucose monitors (CGM). However, little is known about the feasibility of CGM use in TRE interventions in adolescents, or the expected ch...

Descripción completa

Detalles Bibliográficos
Autores principales: Naguib, Monica N., Hegedus, Elizabeth, Raymond, Jennifer K., Goran, Michael I., Salvy, Sarah-Jeanne, Wee, Choo Phei, Durazo-Arvizu, Ramon, Moss, Lilith, Vidmar, Alaina P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914373/
https://www.ncbi.nlm.nih.gov/pubmed/35282464
http://dx.doi.org/10.3389/fendo.2022.841838
_version_ 1784667691893653504
author Naguib, Monica N.
Hegedus, Elizabeth
Raymond, Jennifer K.
Goran, Michael I.
Salvy, Sarah-Jeanne
Wee, Choo Phei
Durazo-Arvizu, Ramon
Moss, Lilith
Vidmar, Alaina P.
author_facet Naguib, Monica N.
Hegedus, Elizabeth
Raymond, Jennifer K.
Goran, Michael I.
Salvy, Sarah-Jeanne
Wee, Choo Phei
Durazo-Arvizu, Ramon
Moss, Lilith
Vidmar, Alaina P.
author_sort Naguib, Monica N.
collection PubMed
description BACKGROUND: Randomized controlled trials of time restricted eating (TRE) in adults have demonstrated improvements in glucose variability as captured by continuous glucose monitors (CGM). However, little is known about the feasibility of CGM use in TRE interventions in adolescents, or the expected changes in glycemic profiles in response to changes in meal-timing. As part of a pilot trial of TRE in adolescents with obesity, this study aimed to 1) assess the feasibility of CGM use, 2) describe baseline glycemic profiles in adolescents with obesity, without diabetes, and 3) compare the difference between glycemic profiles in groups practicing TRE versus control. METHODS: This study leverages data from a 12-week pilot trial (ClinicalTrials.gov Identifier: NCT03954223) of late TRE in adolescents with obesity compared to a prolonged eating window. Feasibility of CGM use was assessed by monitoring 1) the percent wear time of the CGM and 2) responses to satisfaction questionnaires. A computation of summary measures of all glycemic data prior to randomization was done using EasyGV and R. Repeat measures analysis was conducted to assess the change in glycemic variability over time between groups. Review of CGM tracings during periods of 24-hour dietary recall was utilized to describe glycemic excursions. RESULTS: Fifty participants were enrolled in the study and 43 had CGM and dietary recall data available (16.4 + 1.3 years, 64% female, 64% Hispanic, 74% public insurance). There was high adherence to daily CGM wear (96.4%) without negative impacts on daily functioning. There was no significant change in the glycemic variability as measured by standard deviation, mean amplitude glycemic excursion, and glucose area under the curve over the study period between groups. CONCLUSIONS: CGM use appears to be a feasible and acceptable tool to monitor glycemic profiles in adolescents with obesity and may be a helpful strategy to confirm TRE dosage by capturing glycemic excursions compared to self-reported meal timing. There was no effect of TRE on glucose profiles in this study. Further research is needed to investigate how TRE impacts glycemic variability in this age group and to explore if timing of eating window effects these findings.
format Online
Article
Text
id pubmed-8914373
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-89143732022-03-12 Continuous Glucose Monitoring in Adolescents With Obesity: Monitoring of Glucose Profiles, Glycemic Excursions, and Adherence to Time Restricted Eating Programs Naguib, Monica N. Hegedus, Elizabeth Raymond, Jennifer K. Goran, Michael I. Salvy, Sarah-Jeanne Wee, Choo Phei Durazo-Arvizu, Ramon Moss, Lilith Vidmar, Alaina P. Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Randomized controlled trials of time restricted eating (TRE) in adults have demonstrated improvements in glucose variability as captured by continuous glucose monitors (CGM). However, little is known about the feasibility of CGM use in TRE interventions in adolescents, or the expected changes in glycemic profiles in response to changes in meal-timing. As part of a pilot trial of TRE in adolescents with obesity, this study aimed to 1) assess the feasibility of CGM use, 2) describe baseline glycemic profiles in adolescents with obesity, without diabetes, and 3) compare the difference between glycemic profiles in groups practicing TRE versus control. METHODS: This study leverages data from a 12-week pilot trial (ClinicalTrials.gov Identifier: NCT03954223) of late TRE in adolescents with obesity compared to a prolonged eating window. Feasibility of CGM use was assessed by monitoring 1) the percent wear time of the CGM and 2) responses to satisfaction questionnaires. A computation of summary measures of all glycemic data prior to randomization was done using EasyGV and R. Repeat measures analysis was conducted to assess the change in glycemic variability over time between groups. Review of CGM tracings during periods of 24-hour dietary recall was utilized to describe glycemic excursions. RESULTS: Fifty participants were enrolled in the study and 43 had CGM and dietary recall data available (16.4 + 1.3 years, 64% female, 64% Hispanic, 74% public insurance). There was high adherence to daily CGM wear (96.4%) without negative impacts on daily functioning. There was no significant change in the glycemic variability as measured by standard deviation, mean amplitude glycemic excursion, and glucose area under the curve over the study period between groups. CONCLUSIONS: CGM use appears to be a feasible and acceptable tool to monitor glycemic profiles in adolescents with obesity and may be a helpful strategy to confirm TRE dosage by capturing glycemic excursions compared to self-reported meal timing. There was no effect of TRE on glucose profiles in this study. Further research is needed to investigate how TRE impacts glycemic variability in this age group and to explore if timing of eating window effects these findings. Frontiers Media S.A. 2022-02-25 /pmc/articles/PMC8914373/ /pubmed/35282464 http://dx.doi.org/10.3389/fendo.2022.841838 Text en Copyright © 2022 Naguib, Hegedus, Raymond, Goran, Salvy, Wee, Durazo-Arvizu, Moss and Vidmar https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Naguib, Monica N.
Hegedus, Elizabeth
Raymond, Jennifer K.
Goran, Michael I.
Salvy, Sarah-Jeanne
Wee, Choo Phei
Durazo-Arvizu, Ramon
Moss, Lilith
Vidmar, Alaina P.
Continuous Glucose Monitoring in Adolescents With Obesity: Monitoring of Glucose Profiles, Glycemic Excursions, and Adherence to Time Restricted Eating Programs
title Continuous Glucose Monitoring in Adolescents With Obesity: Monitoring of Glucose Profiles, Glycemic Excursions, and Adherence to Time Restricted Eating Programs
title_full Continuous Glucose Monitoring in Adolescents With Obesity: Monitoring of Glucose Profiles, Glycemic Excursions, and Adherence to Time Restricted Eating Programs
title_fullStr Continuous Glucose Monitoring in Adolescents With Obesity: Monitoring of Glucose Profiles, Glycemic Excursions, and Adherence to Time Restricted Eating Programs
title_full_unstemmed Continuous Glucose Monitoring in Adolescents With Obesity: Monitoring of Glucose Profiles, Glycemic Excursions, and Adherence to Time Restricted Eating Programs
title_short Continuous Glucose Monitoring in Adolescents With Obesity: Monitoring of Glucose Profiles, Glycemic Excursions, and Adherence to Time Restricted Eating Programs
title_sort continuous glucose monitoring in adolescents with obesity: monitoring of glucose profiles, glycemic excursions, and adherence to time restricted eating programs
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914373/
https://www.ncbi.nlm.nih.gov/pubmed/35282464
http://dx.doi.org/10.3389/fendo.2022.841838
work_keys_str_mv AT naguibmonican continuousglucosemonitoringinadolescentswithobesitymonitoringofglucoseprofilesglycemicexcursionsandadherencetotimerestrictedeatingprograms
AT hegeduselizabeth continuousglucosemonitoringinadolescentswithobesitymonitoringofglucoseprofilesglycemicexcursionsandadherencetotimerestrictedeatingprograms
AT raymondjenniferk continuousglucosemonitoringinadolescentswithobesitymonitoringofglucoseprofilesglycemicexcursionsandadherencetotimerestrictedeatingprograms
AT goranmichaeli continuousglucosemonitoringinadolescentswithobesitymonitoringofglucoseprofilesglycemicexcursionsandadherencetotimerestrictedeatingprograms
AT salvysarahjeanne continuousglucosemonitoringinadolescentswithobesitymonitoringofglucoseprofilesglycemicexcursionsandadherencetotimerestrictedeatingprograms
AT weechoophei continuousglucosemonitoringinadolescentswithobesitymonitoringofglucoseprofilesglycemicexcursionsandadherencetotimerestrictedeatingprograms
AT durazoarvizuramon continuousglucosemonitoringinadolescentswithobesitymonitoringofglucoseprofilesglycemicexcursionsandadherencetotimerestrictedeatingprograms
AT mosslilith continuousglucosemonitoringinadolescentswithobesitymonitoringofglucoseprofilesglycemicexcursionsandadherencetotimerestrictedeatingprograms
AT vidmaralainap continuousglucosemonitoringinadolescentswithobesitymonitoringofglucoseprofilesglycemicexcursionsandadherencetotimerestrictedeatingprograms