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Inositol triphosphate–triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3

Lysosomes serve as dynamic regulators of cell and organismal physiology by integrating the degradation of macromolecules with receptor and nutrient signaling. Previous studies have established that activation of the transcription factor EB (TFEB) and transcription factor E3 (TFE3) induces the expres...

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Detalles Bibliográficos
Autores principales: Malek, Mouhannad, Wawrzyniak, Anna M., Ebner, Michael, Puchkov, Dmytro, Haucke, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914386/
https://www.ncbi.nlm.nih.gov/pubmed/35182526
http://dx.doi.org/10.1016/j.jbc.2022.101740