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Non-Exonuclease Domain POLE Mutations Associated with Immunotherapy Benefit

Inactivating mutations in the exonuclease domain of POLE induce somatic hypermutation resulting in a high tumor mutation burden (TMB) and are associated with immune checkpoint inhibitor (ICI) benefit. POLE mutations outside the exonuclease domain predicted to be deleterious are also observed in canc...

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Detalles Bibliográficos
Autores principales:	Dong, Sharlene, Zakaria, Heba, Hsiehchen, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Precision Medicine Clinic: Molecular Tumor Board
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914489/ https://www.ncbi.nlm.nih.gov/pubmed/35274726 http://dx.doi.org/10.1093/oncolo/oyac017

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