Inhibition of Protein Kinase CK2 Affects Thymidylate Synthesis Cycle Enzyme Level and Distribution in Human Cancer Cells

Thymidylate synthase (TS), dihydrofolate reductase (DHFR), and serine hydroxymethyltransferase (SHMT) constitute the thymidylate synthesis cycle providing thymidylate for DNA synthesis and repair. Our previous studies indicated that TS and DHFR are the substrates of protein kinase CK2. This work has...

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Detalles Bibliográficos
Autores principales: Wińska, Patrycja, Widło, Łukasz, Senkara, Elżbieta, Koronkiewicz, Mirosława, Cieśla, Jarosław M., Krzyśko, Alicja, Skierka, Katarzyna, Cieśla, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914513/
https://www.ncbi.nlm.nih.gov/pubmed/35281258
http://dx.doi.org/10.3389/fmolb.2022.847829

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