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Hand Pronation–Supination Movement as a Proxy for Remotely Monitoring Gait and Posture Stability in Parkinson’s Disease

The Unified Parkinson’s Disease Rating Scale (UPDRS) is a subjective Parkinson’s Disease (PD) physician scoring/monitoring system. To date, there is no single upper limb wearable/non-contact system that can be used objectively to assess all UPDRS-III motor system subgroups (i.e., tremor (T), rigidit...

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Autores principales: Cakmak, Yusuf Ozgur, Olcek, Can, Ozsoy, Burak, Khwaounjoo, Prashanna, Kiziltan, Gunes, Apaydin, Hulya, Günduz, Aysegul, Oztop Cakmak, Ozgur, Ertan, Sibel, Gursoy-Ozdemir, Yasemin, Gokcay, Didem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915024/
https://www.ncbi.nlm.nih.gov/pubmed/35270972
http://dx.doi.org/10.3390/s22051827
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author Cakmak, Yusuf Ozgur
Olcek, Can
Ozsoy, Burak
Khwaounjoo, Prashanna
Kiziltan, Gunes
Apaydin, Hulya
Günduz, Aysegul
Oztop Cakmak, Ozgur
Ertan, Sibel
Gursoy-Ozdemir, Yasemin
Gokcay, Didem
author_facet Cakmak, Yusuf Ozgur
Olcek, Can
Ozsoy, Burak
Khwaounjoo, Prashanna
Kiziltan, Gunes
Apaydin, Hulya
Günduz, Aysegul
Oztop Cakmak, Ozgur
Ertan, Sibel
Gursoy-Ozdemir, Yasemin
Gokcay, Didem
author_sort Cakmak, Yusuf Ozgur
collection PubMed
description The Unified Parkinson’s Disease Rating Scale (UPDRS) is a subjective Parkinson’s Disease (PD) physician scoring/monitoring system. To date, there is no single upper limb wearable/non-contact system that can be used objectively to assess all UPDRS-III motor system subgroups (i.e., tremor (T), rigidity (R), bradykinesia (B), gait and posture (GP), and bulbar anomalies (BA)). We evaluated the use of a non-contact hand motion tracking system for potential extraction of GP information using forearm pronation–supination (P/S) motion parameters (speed, acceleration, and frequency). Twenty-four patients with idiopathic PD participated, and their UPDRS data were recorded bilaterally by physicians. Pearson’s correlation, regression analyses, and Monte Carlo validation was conducted for all combinations of UPDRS subgroups versus motion parameters. In the 262,125 regression models that were trained and tested, the models within 1% of the lowest error showed that the frequency of P/S contributes to approximately one third of all models; while speed and acceleration also contribute significantly to the prediction of GP from the left-hand motion of right handed patients. In short, the P/S better indicated GP when performed with the non-dominant hand. There was also a significant negative correlation (with medium to large effect size, range: 0.3–0.58) between the P/S speed and the single BA score for both forearms and combined UPDRS score for the dominant hand. This study highlights the potential use of wearable or non-contact systems for forearm P/S to remotely monitor and predict the GP information in PD.
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spelling pubmed-89150242022-03-12 Hand Pronation–Supination Movement as a Proxy for Remotely Monitoring Gait and Posture Stability in Parkinson’s Disease Cakmak, Yusuf Ozgur Olcek, Can Ozsoy, Burak Khwaounjoo, Prashanna Kiziltan, Gunes Apaydin, Hulya Günduz, Aysegul Oztop Cakmak, Ozgur Ertan, Sibel Gursoy-Ozdemir, Yasemin Gokcay, Didem Sensors (Basel) Article The Unified Parkinson’s Disease Rating Scale (UPDRS) is a subjective Parkinson’s Disease (PD) physician scoring/monitoring system. To date, there is no single upper limb wearable/non-contact system that can be used objectively to assess all UPDRS-III motor system subgroups (i.e., tremor (T), rigidity (R), bradykinesia (B), gait and posture (GP), and bulbar anomalies (BA)). We evaluated the use of a non-contact hand motion tracking system for potential extraction of GP information using forearm pronation–supination (P/S) motion parameters (speed, acceleration, and frequency). Twenty-four patients with idiopathic PD participated, and their UPDRS data were recorded bilaterally by physicians. Pearson’s correlation, regression analyses, and Monte Carlo validation was conducted for all combinations of UPDRS subgroups versus motion parameters. In the 262,125 regression models that were trained and tested, the models within 1% of the lowest error showed that the frequency of P/S contributes to approximately one third of all models; while speed and acceleration also contribute significantly to the prediction of GP from the left-hand motion of right handed patients. In short, the P/S better indicated GP when performed with the non-dominant hand. There was also a significant negative correlation (with medium to large effect size, range: 0.3–0.58) between the P/S speed and the single BA score for both forearms and combined UPDRS score for the dominant hand. This study highlights the potential use of wearable or non-contact systems for forearm P/S to remotely monitor and predict the GP information in PD. MDPI 2022-02-25 /pmc/articles/PMC8915024/ /pubmed/35270972 http://dx.doi.org/10.3390/s22051827 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cakmak, Yusuf Ozgur
Olcek, Can
Ozsoy, Burak
Khwaounjoo, Prashanna
Kiziltan, Gunes
Apaydin, Hulya
Günduz, Aysegul
Oztop Cakmak, Ozgur
Ertan, Sibel
Gursoy-Ozdemir, Yasemin
Gokcay, Didem
Hand Pronation–Supination Movement as a Proxy for Remotely Monitoring Gait and Posture Stability in Parkinson’s Disease
title Hand Pronation–Supination Movement as a Proxy for Remotely Monitoring Gait and Posture Stability in Parkinson’s Disease
title_full Hand Pronation–Supination Movement as a Proxy for Remotely Monitoring Gait and Posture Stability in Parkinson’s Disease
title_fullStr Hand Pronation–Supination Movement as a Proxy for Remotely Monitoring Gait and Posture Stability in Parkinson’s Disease
title_full_unstemmed Hand Pronation–Supination Movement as a Proxy for Remotely Monitoring Gait and Posture Stability in Parkinson’s Disease
title_short Hand Pronation–Supination Movement as a Proxy for Remotely Monitoring Gait and Posture Stability in Parkinson’s Disease
title_sort hand pronation–supination movement as a proxy for remotely monitoring gait and posture stability in parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915024/
https://www.ncbi.nlm.nih.gov/pubmed/35270972
http://dx.doi.org/10.3390/s22051827
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