An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir

[Image: see text] The Covid-19 pandemic highlights the urgent need for cost-effective processes to rapidly manufacture antiviral drugs at scale. Here we report a concise biocatalytic process for Molnupiravir, a nucleoside analogue recently approved as an orally available treatment for SARS-CoV-2. Ke...

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Detalles Bibliográficos
Autores principales: Burke, Ashleigh J., Birmingham, William R., Zhuo, Ying, Thorpe, Thomas W., Zucoloto da Costa, Bruna, Crawshaw, Rebecca, Rowles, Ian, Finnigan, James D., Young, Carl, Holgate, Gregory M., Muldowney, Mark P., Charnock, Simon J., Lovelock, Sarah L., Turner, Nicholas J., Green, Anthony P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915250/
https://www.ncbi.nlm.nih.gov/pubmed/35224970
http://dx.doi.org/10.1021/jacs.1c11048

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