Spatial profiling reveals association between WNT pathway activation and T-cell exclusion in acquired resistance of synovial sarcoma to NY-ESO-1 transgenic T-cell therapy

BACKGROUND: Genetically engineered T-cell immunotherapies for adoptive cell transfer (ACT) have emerged as a promising form of cancer treatment, but many of these patients develop recurrent disease. Furthermore, delineating mechanisms of resistance may be challenging since the analysis of bulk tumor...

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Detalles Bibliográficos
Autores principales: Campbell, Katie M, Thaker, Maneesha, Medina, Egmidio, Kalbasi, Anusha, Singh, Arun, Ribas, Antoni, Nowicki, Theodore Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915285/
https://www.ncbi.nlm.nih.gov/pubmed/35264439
http://dx.doi.org/10.1136/jitc-2021-004190

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