Exosomal CD73 from serum of patients with melanoma suppresses lymphocyte functions and is associated with therapy resistance to anti-PD-1 agents

BACKGROUND: CD73 is an ectonucleotidase producing the immunosuppressor mediator adenosine. Elevated levels of circulating CD73 in patients with cancer have been associated with disease progression and poor response to immunotherapy. Immunosuppressive pathways associated with exosomes can affect T-ce...

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Detalles Bibliográficos
Autores principales: Turiello, Roberta, Capone, Mariaelena, Morretta, Elva, Monti, Maria Chiara, Madonna, Gabriele, Azzaro, Rosa, Del Gaudio, Pasquale, Simeone, Ester, Sorrentino, Antonio, Ascierto, Paolo A, Morello, Silvana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915288/
https://www.ncbi.nlm.nih.gov/pubmed/35273100
http://dx.doi.org/10.1136/jitc-2021-004043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915288/
https://www.ncbi.nlm.nih.gov/pubmed/35273100
http://dx.doi.org/10.1136/jitc-2021-004043

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