PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment

BACKGROUND: Oncogenes act in a cell-intrinsic way to promote tumorigenesis. Whether oncogenes also have a cell-extrinsic effect on suppressing the immune response to cancer is less well understood. METHODS: We use an in vivo expression screen of known cancer-associated somatic mutations in mouse syn...

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Detalles Bibliográficos
Autores principales: Collins, Natalie B, Al Abosy, Rose, Miller, Brian C, Bi, Kevin, Zhao, Qihong, Quigley, Michael, Ishizuka, Jeffrey J, Yates, Kathleen B, Pope, Hans W, Manguso, Robert T, Shrestha, Yashaswi, Wadsworth, Marc, Hughes, Travis, Shalek, Alex K, Boehm, Jesse S, Hahn, William C, Doench, John G, Haining, W Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915320/
https://www.ncbi.nlm.nih.gov/pubmed/35264433
http://dx.doi.org/10.1136/jitc-2021-003402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915320/
https://www.ncbi.nlm.nih.gov/pubmed/35264433
http://dx.doi.org/10.1136/jitc-2021-003402

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