Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S

BACKGROUND: Cross-presentation of exogenous antigens in HLA-class I molecules by professional antigen presenting cells (APCs) is crucial for CD8+ T cell function. Recent murine studies show that several non-professional APCs, including cancer-associated fibroblasts (CAFs) also possess this capacity....

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Detalles Bibliográficos
Autores principales: Harryvan, Tom J, Visser, Marten, de Bruin, Linda, Plug, Léonie, Griffioen, Lisa, Mulder, Arend, van Veelen, Peter A, van der Heden van Noort, Gerbrand J, Jongsma, Marlieke LM, Meeuwsen, Miranda H, Wiertz, Emmanuel JHJ, Santegoets, Saskia J, Hardwick, James CH, Van Hall, Thorbald, Neefjes, Jacques, Van der Burg, Sjoerd H, Hawinkels, Lukas JAC, Verdegaal, Els ME
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915372/
https://www.ncbi.nlm.nih.gov/pubmed/35264435
http://dx.doi.org/10.1136/jitc-2021-003591

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