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RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants

With the rapid emergence and spread of SARS-CoV-2 variants, development of vaccines with broad and potent protectivity has become a global priority. Here, we designed a lipid nanoparticle-encapsulated, nucleoside-unmodified mRNA (mRNA-LNP) vaccine encoding the trimerized receptor-binding domain (RBD...

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Detalles Bibliográficos
Autores principales:	Liang, Qingtai, Wang, Yifeng, Zhang, Shuyuan, Sun, Jing, Sun, Wenbo, Li, Jizhou, Liu, Yaping, Li, Mingxi, Cheng, Lin, Jiang, Yuhang, Wang, Ruoke, Zhang, Rui, Yang, Zihan, Ren, Yifei, Chen, Peng, Gao, Peng, Yan, Huayuan, Zhang, Zheng, Zhang, Qi, Shi, Xuanling, Wang, Jianbin, Liu, Wanli, Wang, Xinquan, Ying, Bo, Zhao, Jincun, Qi, Hai, Zhang, Linqi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915453/ https://www.ncbi.nlm.nih.gov/pubmed/35291264 http://dx.doi.org/10.1016/j.isci.2022.104043

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