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Can small drugs predict the intrinsic aqueous solubility of ‘beyond Rule of 5’ big drugs?
The aim of the study was to explore to what extent small molecules (mostly from the Rule of 5 chemical space) can be used to predict the intrinsic aqueous solubility, S(0), of big molecules from beyond the Rule of 5 (bRo5) space. It was demonstrated that the General Solubility Equation (GSE) and the...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Association of Physical Chemists
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915605/ https://www.ncbi.nlm.nih.gov/pubmed/35300304 http://dx.doi.org/10.5599/admet.794 |