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Quantitative Sensory Testing Across Chronic Pain Conditions and Use in Special Populations

Chronic pain imposes a significant burden to the healthcare system and adversely affects patients' quality of life. Traditional subjective assessments, however, do not adequately capture the complex phenomenon of pain, which is influenced by a multitude of factors including environmental, devel...

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Autores principales: Weaver, Kristen R., Griffioen, Mari A., Klinedinst, N. Jennifer, Galik, Elizabeth, Duarte, Ana C., Colloca, Luana, Resnick, Barbara, Dorsey, Susan G., Renn, Cynthia L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915716/
https://www.ncbi.nlm.nih.gov/pubmed/35295425
http://dx.doi.org/10.3389/fpain.2021.779068
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author Weaver, Kristen R.
Griffioen, Mari A.
Klinedinst, N. Jennifer
Galik, Elizabeth
Duarte, Ana C.
Colloca, Luana
Resnick, Barbara
Dorsey, Susan G.
Renn, Cynthia L.
author_facet Weaver, Kristen R.
Griffioen, Mari A.
Klinedinst, N. Jennifer
Galik, Elizabeth
Duarte, Ana C.
Colloca, Luana
Resnick, Barbara
Dorsey, Susan G.
Renn, Cynthia L.
author_sort Weaver, Kristen R.
collection PubMed
description Chronic pain imposes a significant burden to the healthcare system and adversely affects patients' quality of life. Traditional subjective assessments, however, do not adequately capture the complex phenomenon of pain, which is influenced by a multitude of factors including environmental, developmental, genetic, and psychological. Quantitative sensory testing (QST), established as a protocol to examine thermal and mechanical sensory function, offers insight on potential mechanisms contributing to an individual's experience of pain, by assessing their perceived response to standardized delivery of stimuli. Although the use of QST as a research methodology has been described in the literature in reference to specific pain populations, this manuscript details application of QST across a variety of chronic pain conditions. Specific conditions include lower extremity chronic pain, knee osteoarthritis, chronic low back pain, temporomandibular joint disorder, and irritable bowel syndrome. Furthermore, we describe the use of QST in placebo/nocebo research, and discuss the use of QST in vulnerable populations such as those with dementia. We illustrate how the evaluation of peripheral sensory nerve function holds clinical promise in targeting interventions, and how using QST can enhance patient education regarding prognostic outcomes with particular treatments. Incorporation of QST methodology in research investigations may facilitate the identification of common mechanisms underlying chronic pain conditions, guide the development of non-pharmacological behavioral interventions to reduce pain and pain-related morbidity, and enhance our efforts toward reducing the burden of chronic pain.
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spelling pubmed-89157162022-03-15 Quantitative Sensory Testing Across Chronic Pain Conditions and Use in Special Populations Weaver, Kristen R. Griffioen, Mari A. Klinedinst, N. Jennifer Galik, Elizabeth Duarte, Ana C. Colloca, Luana Resnick, Barbara Dorsey, Susan G. Renn, Cynthia L. Front Pain Res (Lausanne) Pain Research Chronic pain imposes a significant burden to the healthcare system and adversely affects patients' quality of life. Traditional subjective assessments, however, do not adequately capture the complex phenomenon of pain, which is influenced by a multitude of factors including environmental, developmental, genetic, and psychological. Quantitative sensory testing (QST), established as a protocol to examine thermal and mechanical sensory function, offers insight on potential mechanisms contributing to an individual's experience of pain, by assessing their perceived response to standardized delivery of stimuli. Although the use of QST as a research methodology has been described in the literature in reference to specific pain populations, this manuscript details application of QST across a variety of chronic pain conditions. Specific conditions include lower extremity chronic pain, knee osteoarthritis, chronic low back pain, temporomandibular joint disorder, and irritable bowel syndrome. Furthermore, we describe the use of QST in placebo/nocebo research, and discuss the use of QST in vulnerable populations such as those with dementia. We illustrate how the evaluation of peripheral sensory nerve function holds clinical promise in targeting interventions, and how using QST can enhance patient education regarding prognostic outcomes with particular treatments. Incorporation of QST methodology in research investigations may facilitate the identification of common mechanisms underlying chronic pain conditions, guide the development of non-pharmacological behavioral interventions to reduce pain and pain-related morbidity, and enhance our efforts toward reducing the burden of chronic pain. Frontiers Media S.A. 2022-01-28 /pmc/articles/PMC8915716/ /pubmed/35295425 http://dx.doi.org/10.3389/fpain.2021.779068 Text en Copyright © 2022 Weaver, Griffioen, Klinedinst, Galik, Duarte, Colloca, Resnick, Dorsey and Renn. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pain Research
Weaver, Kristen R.
Griffioen, Mari A.
Klinedinst, N. Jennifer
Galik, Elizabeth
Duarte, Ana C.
Colloca, Luana
Resnick, Barbara
Dorsey, Susan G.
Renn, Cynthia L.
Quantitative Sensory Testing Across Chronic Pain Conditions and Use in Special Populations
title Quantitative Sensory Testing Across Chronic Pain Conditions and Use in Special Populations
title_full Quantitative Sensory Testing Across Chronic Pain Conditions and Use in Special Populations
title_fullStr Quantitative Sensory Testing Across Chronic Pain Conditions and Use in Special Populations
title_full_unstemmed Quantitative Sensory Testing Across Chronic Pain Conditions and Use in Special Populations
title_short Quantitative Sensory Testing Across Chronic Pain Conditions and Use in Special Populations
title_sort quantitative sensory testing across chronic pain conditions and use in special populations
topic Pain Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915716/
https://www.ncbi.nlm.nih.gov/pubmed/35295425
http://dx.doi.org/10.3389/fpain.2021.779068
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