Discovery of a functionally selective ghrelin receptor (GHSR(1a)) ligand for modulating brain dopamine

The growth hormone secretagogue receptor-1a (GHSR(1a)) is the cognate G protein–coupled receptor (GPCR) for the peptide hormone ghrelin. GHSR(1a) is a promising therapeutic target for a wide range of metabolic, age-related, and central nervous system (CNS)–based conditions. In addition, growing evid...

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Detalles Bibliográficos
Autores principales: Gross, J. D., Kim, D. W., Zhou, Y., Jansen, D., Slosky, L. M., Clark, N. B., Ray, C. R., Hu, X., Southall, N., Wang, A., Xu, X., Barnaeva, E., Wetsel, W. C., Ferrer, M., Marugan, J. J., Caron, M. G., Barak, L. S., Toth, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915830/
https://www.ncbi.nlm.nih.gov/pubmed/35239443
http://dx.doi.org/10.1073/pnas.2112397119

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