Using Live Imaging and FUCCI Embryonic Stem Cells to Rank DevTox Risks: Adverse Growth Effects of PFOA Compared With DEP Are 26 Times Faster, 1,000 Times More Sensitive, and 13 Times Greater in Magnitude

Fluorescent ubiquitination-based cell cycle indicator (FUCCI) embryonic stem cells (ESCs), which fluoresce green during the S-G2-M phases, generate an S-shaped curve for the accumulation of cells during normal stemness (NS) culture with leukemia-inhibitory factor (LIF). Since it was hypothesized tha...

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Detalles Bibliográficos
Autores principales: Abdulhasan, Mohammed, Ruden, Ximena, You, Yuan, Harris, Sean M., Ruden, Douglas M., Awonuga, Awoniyi O., Alvero, Ayesha, Puscheck, Elizabeth E., Rappolee, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915856/
https://www.ncbi.nlm.nih.gov/pubmed/35295126
http://dx.doi.org/10.3389/ftox.2021.709747

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