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Radiolabeling of Nanomaterials: Advantages and Challenges
Quantifying the distribution of nanomaterials in complex samples is of great significance to the toxicological research of nanomaterials as well as their clinical applications. Radiotracer technology is a powerful tool for biological and environmental tracing of nanomaterials because it has the adva...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915866/ https://www.ncbi.nlm.nih.gov/pubmed/35295152 http://dx.doi.org/10.3389/ftox.2021.753316 |
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author | Dai, Wanqin Zhang, Junzhe Wang, Yun Jiao, Chunlei Song, Zhuda Ma, Yuhui Ding, Yayun Zhang, Zhiyong He, Xiao |
author_facet | Dai, Wanqin Zhang, Junzhe Wang, Yun Jiao, Chunlei Song, Zhuda Ma, Yuhui Ding, Yayun Zhang, Zhiyong He, Xiao |
author_sort | Dai, Wanqin |
collection | PubMed |
description | Quantifying the distribution of nanomaterials in complex samples is of great significance to the toxicological research of nanomaterials as well as their clinical applications. Radiotracer technology is a powerful tool for biological and environmental tracing of nanomaterials because it has the advantages of high sensitivity and high reliability, and can be matched with some spatially resolved technologies for non-invasive, real-time detection. However, the radiolabeling operation of nanomaterials is relatively complicated, and fundamental studies on how to optimize the experimental procedures for the best radiolabeling of nanomaterials are still needed. This minireview looks back into the methods of radiolabeling of nanomaterials in previous work, and highlights the superiority of the “last-step” labeling strategy. At the same time, the problems existing in the stability test of radiolabeling and the suggestions for further improvement are also addressed. |
format | Online Article Text |
id | pubmed-8915866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89158662022-03-15 Radiolabeling of Nanomaterials: Advantages and Challenges Dai, Wanqin Zhang, Junzhe Wang, Yun Jiao, Chunlei Song, Zhuda Ma, Yuhui Ding, Yayun Zhang, Zhiyong He, Xiao Front Toxicol Toxicology Quantifying the distribution of nanomaterials in complex samples is of great significance to the toxicological research of nanomaterials as well as their clinical applications. Radiotracer technology is a powerful tool for biological and environmental tracing of nanomaterials because it has the advantages of high sensitivity and high reliability, and can be matched with some spatially resolved technologies for non-invasive, real-time detection. However, the radiolabeling operation of nanomaterials is relatively complicated, and fundamental studies on how to optimize the experimental procedures for the best radiolabeling of nanomaterials are still needed. This minireview looks back into the methods of radiolabeling of nanomaterials in previous work, and highlights the superiority of the “last-step” labeling strategy. At the same time, the problems existing in the stability test of radiolabeling and the suggestions for further improvement are also addressed. Frontiers Media S.A. 2021-12-13 /pmc/articles/PMC8915866/ /pubmed/35295152 http://dx.doi.org/10.3389/ftox.2021.753316 Text en Copyright © 2021 Dai, Zhang, Wang, Jiao, Song, Ma, Ding, Zhang and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Toxicology Dai, Wanqin Zhang, Junzhe Wang, Yun Jiao, Chunlei Song, Zhuda Ma, Yuhui Ding, Yayun Zhang, Zhiyong He, Xiao Radiolabeling of Nanomaterials: Advantages and Challenges |
title | Radiolabeling of Nanomaterials: Advantages and Challenges |
title_full | Radiolabeling of Nanomaterials: Advantages and Challenges |
title_fullStr | Radiolabeling of Nanomaterials: Advantages and Challenges |
title_full_unstemmed | Radiolabeling of Nanomaterials: Advantages and Challenges |
title_short | Radiolabeling of Nanomaterials: Advantages and Challenges |
title_sort | radiolabeling of nanomaterials: advantages and challenges |
topic | Toxicology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915866/ https://www.ncbi.nlm.nih.gov/pubmed/35295152 http://dx.doi.org/10.3389/ftox.2021.753316 |
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