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The Challenges of 21st Century Neurotoxicology: The Case of Neurotoxicology Applied to Nanomaterials
After a short background discussing engineered nanomaterials (ENMs) and their physicochemical properties and applications, the present perspective paper highlights the main specific points that need to be considered when examining the question of neurotoxicity of nanomaterials. It underlines the nec...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915904/ https://www.ncbi.nlm.nih.gov/pubmed/35295119 http://dx.doi.org/10.3389/ftox.2021.629256 |
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author | Bencsik, Anna Lestaevel, Philippe |
author_facet | Bencsik, Anna Lestaevel, Philippe |
author_sort | Bencsik, Anna |
collection | PubMed |
description | After a short background discussing engineered nanomaterials (ENMs) and their physicochemical properties and applications, the present perspective paper highlights the main specific points that need to be considered when examining the question of neurotoxicity of nanomaterials. It underlines the necessity to integrate parameters, specific tools, and tests from multiple sources that make neurotoxicology when applied to nanomaterials particularly complex. Bringing together the knowledge of multiple disciplines e.g., nanotoxicology to neurotoxicology, is necessary to build integrated neurotoxicology for the third decade of the 21st Century. This article focuses on the greatest challenges and opportunities offered by this specific field. It highlights the scientific, methodological, political, regulatory, and educational issues. Scientific and methodological challenges include the determination of ENMs physicochemical parameters, the lack of information about protein corona modes of action, target organs, and cells and dose– response functions of ENMs. The need of standardization of data collection and harmonization of dedicated neurotoxicological protocols are also addressed. This article highlights how to address those challenges through innovative methods and tools, and our work also ventures to sketch the first list of substances that should be urgently prioritized for human modern neurotoxicology. Finally, political support with dedicated funding at the national and international levels must also be used to engage the communities concerned to set up dedicated educational program on this novel field. |
format | Online Article Text |
id | pubmed-8915904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89159042022-03-15 The Challenges of 21st Century Neurotoxicology: The Case of Neurotoxicology Applied to Nanomaterials Bencsik, Anna Lestaevel, Philippe Front Toxicol Toxicology After a short background discussing engineered nanomaterials (ENMs) and their physicochemical properties and applications, the present perspective paper highlights the main specific points that need to be considered when examining the question of neurotoxicity of nanomaterials. It underlines the necessity to integrate parameters, specific tools, and tests from multiple sources that make neurotoxicology when applied to nanomaterials particularly complex. Bringing together the knowledge of multiple disciplines e.g., nanotoxicology to neurotoxicology, is necessary to build integrated neurotoxicology for the third decade of the 21st Century. This article focuses on the greatest challenges and opportunities offered by this specific field. It highlights the scientific, methodological, political, regulatory, and educational issues. Scientific and methodological challenges include the determination of ENMs physicochemical parameters, the lack of information about protein corona modes of action, target organs, and cells and dose– response functions of ENMs. The need of standardization of data collection and harmonization of dedicated neurotoxicological protocols are also addressed. This article highlights how to address those challenges through innovative methods and tools, and our work also ventures to sketch the first list of substances that should be urgently prioritized for human modern neurotoxicology. Finally, political support with dedicated funding at the national and international levels must also be used to engage the communities concerned to set up dedicated educational program on this novel field. Frontiers Media S.A. 2021-02-18 /pmc/articles/PMC8915904/ /pubmed/35295119 http://dx.doi.org/10.3389/ftox.2021.629256 Text en Copyright © 2021 Bencsik and Lestaevel. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Toxicology Bencsik, Anna Lestaevel, Philippe The Challenges of 21st Century Neurotoxicology: The Case of Neurotoxicology Applied to Nanomaterials |
title | The Challenges of 21st Century Neurotoxicology: The Case of Neurotoxicology Applied to Nanomaterials |
title_full | The Challenges of 21st Century Neurotoxicology: The Case of Neurotoxicology Applied to Nanomaterials |
title_fullStr | The Challenges of 21st Century Neurotoxicology: The Case of Neurotoxicology Applied to Nanomaterials |
title_full_unstemmed | The Challenges of 21st Century Neurotoxicology: The Case of Neurotoxicology Applied to Nanomaterials |
title_short | The Challenges of 21st Century Neurotoxicology: The Case of Neurotoxicology Applied to Nanomaterials |
title_sort | challenges of 21st century neurotoxicology: the case of neurotoxicology applied to nanomaterials |
topic | Toxicology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915904/ https://www.ncbi.nlm.nih.gov/pubmed/35295119 http://dx.doi.org/10.3389/ftox.2021.629256 |
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