Structural basis for impaired 5′ processing of a mutant tRNA associated with defects in neuronal homeostasis

n-Tr20 is a neuron-specific, cytoplasmic transfer RNA(Arg)(UCU) (tRNA(Arg)(UCU)) isodecoder that affects seizure susceptibility, neuronal excitability, and translation signaling in mice. In addition, the C50U substitution in n-Tr20 (n-Tr20(C50U)), which is found in the widely used C57BL/6J (B6J) inb...

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Detalles Bibliográficos
Autores principales: Lai, Lien B., Lai, Stella M., Szymanski, Eric S., Kapur, Mridu, Choi, Edric K., Al-Hashimi, Hashim M., Ackerman, Susan L., Gopalan, Venkat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915964/
https://www.ncbi.nlm.nih.gov/pubmed/35238631
http://dx.doi.org/10.1073/pnas.2119529119

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