Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis

Metformin exerts its plasma glucose-lowering therapeutic effect primarily through inhibition of hepatic gluconeogenesis. However, the precise molecular mechanism by which metformin inhibits hepatic gluconeogenesis is still unclear. Although inhibition of mitochondrial complex I is frequently invoked...

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Detalles Bibliográficos
Autores principales: LaMoia, Traci E., Butrico, Gina M., Kalpage, Hasini A., Goedeke, Leigh, Hubbard, Brandon T., Vatner, Daniel F., Gaspar, Rafael C., Zhang, Xian-Man, Cline, Gary W., Nakahara, Keita, Woo, Seungwan, Shimada, Atsuhiro, Hüttemann, Maik, Shulman, Gerald I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916010/
https://www.ncbi.nlm.nih.gov/pubmed/35238637
http://dx.doi.org/10.1073/pnas.2122287119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916010/
https://www.ncbi.nlm.nih.gov/pubmed/35238637
http://dx.doi.org/10.1073/pnas.2122287119

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