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Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome

OBJECTIVE: FAM19A5 plays an essential role in the development and acute or chronic inflammation of the central nervous system. The present study aimed to explore the association between FAM19A5 and cerebral small vessel disease (cSVD). METHODS: A total of 344 recent small subcortical infarct (RSSI)...

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Autores principales: Hao, Zhongnan, Yang, Shaonan, Yin, Ruihua, Wei, Jin, Wang, Yuan, Pan, Xudong, Ma, Aijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916029/
https://www.ncbi.nlm.nih.gov/pubmed/35282278
http://dx.doi.org/10.7717/peerj.13101
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author Hao, Zhongnan
Yang, Shaonan
Yin, Ruihua
Wei, Jin
Wang, Yuan
Pan, Xudong
Ma, Aijun
author_facet Hao, Zhongnan
Yang, Shaonan
Yin, Ruihua
Wei, Jin
Wang, Yuan
Pan, Xudong
Ma, Aijun
author_sort Hao, Zhongnan
collection PubMed
description OBJECTIVE: FAM19A5 plays an essential role in the development and acute or chronic inflammation of the central nervous system. The present study aimed to explore the association between FAM19A5 and cerebral small vessel disease (cSVD). METHODS: A total of 344 recent small subcortical infarct (RSSI) patients and 265 healthy controls were included in this study. The difference in the FAM19A5 level between the two groups was compared and the correlation between FAM19A5 and cerebral infarction volume was analyzed. Also, the association between FAM19A5 and the total magnetic resonance imaging (MRI) burden with its imaging characteristics was explored. Moreover, the correspondence of FAM19A5 with the outcome was assessed via Δ National Institutes of Health Stroke Scale score (NIHSS) and the percentage of NIHSS improvement. RESULTS: FAM19A5 was highly expressed in the RSSI group (P = 0.023), showing a positive correlation with cerebral infarction volume (P < 0.01). It was positively correlated with total MRI cSVD burden (P < 0.001) and reflected the severity of white matter hyperintensity (WMH) (P < 0.01) and enlarged perivascular space (EPVS) (P < 0.01), but did not show any association with cerebral microbleed (CMB) and lacune. Moreover, FAM19A5 suggested a larger Δ NIHSS (P = 0.021) and NIHSS improvement percentage (P = 0.007). CONCLUSION: Serum FAM19A5 was increased in RSSI and positively correlated with the infarct volume. It also reflects the total MRI burden of cSVD, of which the imaging characteristics are positively correlated with WMH and EPVS. In addition, higher FAM19A5 levels reflect better outcomes in RSSI patients.
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spelling pubmed-89160292022-03-12 Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome Hao, Zhongnan Yang, Shaonan Yin, Ruihua Wei, Jin Wang, Yuan Pan, Xudong Ma, Aijun PeerJ Cardiology OBJECTIVE: FAM19A5 plays an essential role in the development and acute or chronic inflammation of the central nervous system. The present study aimed to explore the association between FAM19A5 and cerebral small vessel disease (cSVD). METHODS: A total of 344 recent small subcortical infarct (RSSI) patients and 265 healthy controls were included in this study. The difference in the FAM19A5 level between the two groups was compared and the correlation between FAM19A5 and cerebral infarction volume was analyzed. Also, the association between FAM19A5 and the total magnetic resonance imaging (MRI) burden with its imaging characteristics was explored. Moreover, the correspondence of FAM19A5 with the outcome was assessed via Δ National Institutes of Health Stroke Scale score (NIHSS) and the percentage of NIHSS improvement. RESULTS: FAM19A5 was highly expressed in the RSSI group (P = 0.023), showing a positive correlation with cerebral infarction volume (P < 0.01). It was positively correlated with total MRI cSVD burden (P < 0.001) and reflected the severity of white matter hyperintensity (WMH) (P < 0.01) and enlarged perivascular space (EPVS) (P < 0.01), but did not show any association with cerebral microbleed (CMB) and lacune. Moreover, FAM19A5 suggested a larger Δ NIHSS (P = 0.021) and NIHSS improvement percentage (P = 0.007). CONCLUSION: Serum FAM19A5 was increased in RSSI and positively correlated with the infarct volume. It also reflects the total MRI burden of cSVD, of which the imaging characteristics are positively correlated with WMH and EPVS. In addition, higher FAM19A5 levels reflect better outcomes in RSSI patients. PeerJ Inc. 2022-03-08 /pmc/articles/PMC8916029/ /pubmed/35282278 http://dx.doi.org/10.7717/peerj.13101 Text en ©2022 Hao et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Cardiology
Hao, Zhongnan
Yang, Shaonan
Yin, Ruihua
Wei, Jin
Wang, Yuan
Pan, Xudong
Ma, Aijun
Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome
title Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome
title_full Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome
title_fullStr Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome
title_full_unstemmed Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome
title_short Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome
title_sort increased level of fam19a5 is associated with cerebral small vessel disease and leads to a better outcome
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916029/
https://www.ncbi.nlm.nih.gov/pubmed/35282278
http://dx.doi.org/10.7717/peerj.13101
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