Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice

Spinocerebellar ataxias (SCAs) are a group of genetic diseases characterized by progressive ataxia and neurodegeneration, often in cerebellar Purkinje neurons. A SCA1 mouse model, Pcp2-ATXN1[30Q]D776, has severe ataxia in absence of progressive Purkinje neuron degeneration and death. Previous RNA-se...

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Detalles Bibliográficos
Autores principales: Wozniak, Emily A.L., Chen, Zhao, Paul, Sharan, Yang, Praseuth, Figueroa, Karla P., Friedrich, Jill, Tschumperlin, Tyler, Berken, Michael, Ingram, Melissa, Henzler, Christine, Pulst, Stefan M., Orr, Harry T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916043/
https://www.ncbi.nlm.nih.gov/pubmed/34644575
http://dx.doi.org/10.1016/j.celrep.2021.109831

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