Cargando…
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes
Aberrant induction of type I IFN is a hallmark of the inherited encephalopathy Aicardi-Goutières syndrome (AGS), but the mechanisms triggering disease in the human central nervous system (CNS) remain elusive. Here, we generated human models of AGS using genetically modified and patient-derived pluri...
Autores principales: | Giordano, Anna Maria Sole, Luciani, Marco, Gatto, Francesca, Abou Alezz, Monah, Beghè, Chiara, Della Volpe, Lucrezia, Migliara, Alessandro, Valsoni, Sara, Genua, Marco, Dzieciatkowska, Monika, Frati, Giacomo, Tahraoui-Bories, Julie, Giliani, Silvia Clara, Orcesi, Simona, Fazzi, Elisa, Ostuni, Renato, D’Alessandro, Angelo, Di Micco, Raffaella, Merelli, Ivan, Lombardo, Angelo, Reijns, Martin A.M., Gromak, Natalia, Gritti, Angela, Kajaste-Rudnitski, Anna |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916121/ https://www.ncbi.nlm.nih.gov/pubmed/35262626 http://dx.doi.org/10.1084/jem.20211121 |
Ejemplares similares
-
Treatment response to Janus kinase inhibitor in a child affected by Aicardi‐Goutières syndrome
por: Galli, Jessica, et al.
Publicado: (2023) -
Case Report: The JAK-Inhibitor Ruxolitinib Use in Aicardi-Goutieres Syndrome Due to ADAR1 Mutation
por: Cattalini, Marco, et al.
Publicado: (2021) -
Family History of Autoimmune Disease in Patients with Aicardi-Goutières Syndrome
por: Schmidt, Johanna L., et al.
Publicado: (2012) -
Protocol to differentiate monolayer human induced pluripotent stem cells into inflammatory responsive astrocytes
por: Giordano, Anna Maria Sole, et al.
Publicado: (2023) -
IFN-α levels in ruxolitinib-treatead Aicardi-Goutières patient during SARS-CoV-2 infection: A case report
por: Badolato, Raffaele, et al.
Publicado: (2021)