Baclofen-induced neurotoxicity in chronic kidney disease: Is there a safe dose?

Most cases of Baclofen toxicity have been reported in patients with impaired kidney functions, within a few days to weeks after ingestion. We report three cases of Baclofen induced encephalopathy in chronic kidney disease patients; two developed encephalopathy within 6–8 h after ingestion of a singl...

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Detalles Bibliográficos
Autores principales: Varma, Prem P., Bajpai, Geet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916148/
https://www.ncbi.nlm.nih.gov/pubmed/35283571
http://dx.doi.org/10.4103/ijn.IJN_330_20
Descripción
Sumario:Most cases of Baclofen toxicity have been reported in patients with impaired kidney functions, within a few days to weeks after ingestion. We report three cases of Baclofen induced encephalopathy in chronic kidney disease patients; two developed encephalopathy within 6–8 h after ingestion of a single tablet and third on 4(th) day of consuming 2.5 mg twice daily dose. All three cases recovered fully following haemodialysis treatment.

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