Baclofen-induced neurotoxicity in chronic kidney disease: Is there a safe dose?

Most cases of Baclofen toxicity have been reported in patients with impaired kidney functions, within a few days to weeks after ingestion. We report three cases of Baclofen induced encephalopathy in chronic kidney disease patients; two developed encephalopathy within 6–8 h after ingestion of a singl...

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Detalles Bibliográficos
Autores principales: Varma, Prem P., Bajpai, Geet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916148/
https://www.ncbi.nlm.nih.gov/pubmed/35283571
http://dx.doi.org/10.4103/ijn.IJN_330_20
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author Varma, Prem P.
Bajpai, Geet
author_facet Varma, Prem P.
Bajpai, Geet
author_sort Varma, Prem P.
collection PubMed
description Most cases of Baclofen toxicity have been reported in patients with impaired kidney functions, within a few days to weeks after ingestion. We report three cases of Baclofen induced encephalopathy in chronic kidney disease patients; two developed encephalopathy within 6–8 h after ingestion of a single tablet and third on 4(th) day of consuming 2.5 mg twice daily dose. All three cases recovered fully following haemodialysis treatment.
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spelling pubmed-89161482022-03-12 Baclofen-induced neurotoxicity in chronic kidney disease: Is there a safe dose? Varma, Prem P. Bajpai, Geet Indian J Nephrol Case Report Most cases of Baclofen toxicity have been reported in patients with impaired kidney functions, within a few days to weeks after ingestion. We report three cases of Baclofen induced encephalopathy in chronic kidney disease patients; two developed encephalopathy within 6–8 h after ingestion of a single tablet and third on 4(th) day of consuming 2.5 mg twice daily dose. All three cases recovered fully following haemodialysis treatment. Wolters Kluwer - Medknow 2022 2022-01-05 /pmc/articles/PMC8916148/ /pubmed/35283571 http://dx.doi.org/10.4103/ijn.IJN_330_20 Text en Copyright: © 2022 Indian Journal of Nephrology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Varma, Prem P.
Bajpai, Geet
Baclofen-induced neurotoxicity in chronic kidney disease: Is there a safe dose?
title Baclofen-induced neurotoxicity in chronic kidney disease: Is there a safe dose?
title_full Baclofen-induced neurotoxicity in chronic kidney disease: Is there a safe dose?
title_fullStr Baclofen-induced neurotoxicity in chronic kidney disease: Is there a safe dose?
title_full_unstemmed Baclofen-induced neurotoxicity in chronic kidney disease: Is there a safe dose?
title_short Baclofen-induced neurotoxicity in chronic kidney disease: Is there a safe dose?
title_sort baclofen-induced neurotoxicity in chronic kidney disease: is there a safe dose?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916148/
https://www.ncbi.nlm.nih.gov/pubmed/35283571
http://dx.doi.org/10.4103/ijn.IJN_330_20
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