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Fertility preservation in transgender and non-binary adolescents and young adults

Although 37.5–51% of transgender adults state they would’ve considered freezing gametes before gender-affirming therapy if offered and 24–25.8% of transgender adolescents express interest in having biological children, less than 5% of transgender adolescents have opted for fertility preservation. We...

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Detalles Bibliográficos
Autores principales: Cooper, Holly C., Long, Jin, Aye, Tandy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916634/
https://www.ncbi.nlm.nih.gov/pubmed/35275955
http://dx.doi.org/10.1371/journal.pone.0265043
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author Cooper, Holly C.
Long, Jin
Aye, Tandy
author_facet Cooper, Holly C.
Long, Jin
Aye, Tandy
author_sort Cooper, Holly C.
collection PubMed
description Although 37.5–51% of transgender adults state they would’ve considered freezing gametes before gender-affirming therapy if offered and 24–25.8% of transgender adolescents express interest in having biological children, less than 5% of transgender adolescents have opted for fertility preservation. We sought to assess fertility preservation utilization in our multidisciplinary adolescent gender clinic. We also aimed to identify fertility preservation utilization and interest among non-binary adolescents and young adults. A retrospective review was conducted of patients seen in the Stanford Pediatric & Adolescent Gender Clinic from October 2015 through March 2019 who were >10 years of age at initial visit. All individuals with documented discussion of fertility preservation were offered referral for formal fertility preservation consultation but only 24% of patients accepted. Only 6.8% of individuals subsequently underwent fertility preservation (n = 9). Transfeminine adolescents are more likely to pursue fertility preservation than transmasculine adolescents (p = 0.01). The rate of fertility preservation in non-binary adolescents did not significantly differ from those in transfeminine adolescents (p = 1.00) or transmasculine adolescents (p = 0.31). Although only one non-binary individual underwent fertility preservation, several more expressed interest with 36% accepting referral (n = 4) and 27% being seen in consultation (n = 3). Despite offering fertility preservation with designated members of a gender clinic team, utilization remains low in transgender adolescents. Additionally, non-binary adolescents and their families are interested in fertility preservation and referrals should be offered to these individuals. Further studies and advocacy are required to continue to address fertility needs of transgender adolescents.
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spelling pubmed-89166342022-03-12 Fertility preservation in transgender and non-binary adolescents and young adults Cooper, Holly C. Long, Jin Aye, Tandy PLoS One Research Article Although 37.5–51% of transgender adults state they would’ve considered freezing gametes before gender-affirming therapy if offered and 24–25.8% of transgender adolescents express interest in having biological children, less than 5% of transgender adolescents have opted for fertility preservation. We sought to assess fertility preservation utilization in our multidisciplinary adolescent gender clinic. We also aimed to identify fertility preservation utilization and interest among non-binary adolescents and young adults. A retrospective review was conducted of patients seen in the Stanford Pediatric & Adolescent Gender Clinic from October 2015 through March 2019 who were >10 years of age at initial visit. All individuals with documented discussion of fertility preservation were offered referral for formal fertility preservation consultation but only 24% of patients accepted. Only 6.8% of individuals subsequently underwent fertility preservation (n = 9). Transfeminine adolescents are more likely to pursue fertility preservation than transmasculine adolescents (p = 0.01). The rate of fertility preservation in non-binary adolescents did not significantly differ from those in transfeminine adolescents (p = 1.00) or transmasculine adolescents (p = 0.31). Although only one non-binary individual underwent fertility preservation, several more expressed interest with 36% accepting referral (n = 4) and 27% being seen in consultation (n = 3). Despite offering fertility preservation with designated members of a gender clinic team, utilization remains low in transgender adolescents. Additionally, non-binary adolescents and their families are interested in fertility preservation and referrals should be offered to these individuals. Further studies and advocacy are required to continue to address fertility needs of transgender adolescents. Public Library of Science 2022-03-11 /pmc/articles/PMC8916634/ /pubmed/35275955 http://dx.doi.org/10.1371/journal.pone.0265043 Text en © 2022 Cooper et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Cooper, Holly C.
Long, Jin
Aye, Tandy
Fertility preservation in transgender and non-binary adolescents and young adults
title Fertility preservation in transgender and non-binary adolescents and young adults
title_full Fertility preservation in transgender and non-binary adolescents and young adults
title_fullStr Fertility preservation in transgender and non-binary adolescents and young adults
title_full_unstemmed Fertility preservation in transgender and non-binary adolescents and young adults
title_short Fertility preservation in transgender and non-binary adolescents and young adults
title_sort fertility preservation in transgender and non-binary adolescents and young adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916634/
https://www.ncbi.nlm.nih.gov/pubmed/35275955
http://dx.doi.org/10.1371/journal.pone.0265043
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