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Impact of catch-up human papillomavirus vaccination on cervical conization rate in a real-life population in France

OBJECTIVE: To evaluate the impact of catch-up human papillomavirus (HPV) vaccination on conization rates in France in a large population-based study. METHODS: We conducted a retrospective real-life cohort study on data collected prospectively by French National Health Insurance. Echantillon générali...

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Autores principales: Eliès, Antoine, Bonneau, Claire, Houzard, Sophie, Rouzier, Roman, Héquet, Delphine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916646/
https://www.ncbi.nlm.nih.gov/pubmed/35275961
http://dx.doi.org/10.1371/journal.pone.0264821
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author Eliès, Antoine
Bonneau, Claire
Houzard, Sophie
Rouzier, Roman
Héquet, Delphine
author_facet Eliès, Antoine
Bonneau, Claire
Houzard, Sophie
Rouzier, Roman
Héquet, Delphine
author_sort Eliès, Antoine
collection PubMed
description OBJECTIVE: To evaluate the impact of catch-up human papillomavirus (HPV) vaccination on conization rates in France in a large population-based study. METHODS: We conducted a retrospective real-life cohort study on data collected prospectively by French National Health Insurance. Echantillon généralistes des bénéficiaires (EGB) is a database composed of demographic and health care utilization data for a 1/97(th) sample of the French population. We extracted data about all women born between 1983 and 1991, corresponding to the catch-up population (vaccination after 14 years old) at the time of implementation of HPV vaccination. The primary outcome was the occurrence of conization (all types of procedures) compared between vaccinated and non-vaccinated women. RESULTS: The cohort consisted of 42,452 women. Vaccination coverage (at least one dose) was low (9.8%, n = 4,129), but increased with time from vaccine implementation, from 0% in the 1983 cohort to 31% in the 1991 cohort. The conization rate was 1% for the overall population. The risk of conization for women between the ages of 19 and 30 years was reduced in the vaccinated group with a Hazard Ratio (HR) of 0.59 (95% CI[0.39–0.90]; p = 0.043). CONCLUSIONS: With a 10-year follow-up, catch-up HPV vaccination is associated with risk reduction of conization between the ages of 19 and 30.
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spelling pubmed-89166462022-03-12 Impact of catch-up human papillomavirus vaccination on cervical conization rate in a real-life population in France Eliès, Antoine Bonneau, Claire Houzard, Sophie Rouzier, Roman Héquet, Delphine PLoS One Research Article OBJECTIVE: To evaluate the impact of catch-up human papillomavirus (HPV) vaccination on conization rates in France in a large population-based study. METHODS: We conducted a retrospective real-life cohort study on data collected prospectively by French National Health Insurance. Echantillon généralistes des bénéficiaires (EGB) is a database composed of demographic and health care utilization data for a 1/97(th) sample of the French population. We extracted data about all women born between 1983 and 1991, corresponding to the catch-up population (vaccination after 14 years old) at the time of implementation of HPV vaccination. The primary outcome was the occurrence of conization (all types of procedures) compared between vaccinated and non-vaccinated women. RESULTS: The cohort consisted of 42,452 women. Vaccination coverage (at least one dose) was low (9.8%, n = 4,129), but increased with time from vaccine implementation, from 0% in the 1983 cohort to 31% in the 1991 cohort. The conization rate was 1% for the overall population. The risk of conization for women between the ages of 19 and 30 years was reduced in the vaccinated group with a Hazard Ratio (HR) of 0.59 (95% CI[0.39–0.90]; p = 0.043). CONCLUSIONS: With a 10-year follow-up, catch-up HPV vaccination is associated with risk reduction of conization between the ages of 19 and 30. Public Library of Science 2022-03-11 /pmc/articles/PMC8916646/ /pubmed/35275961 http://dx.doi.org/10.1371/journal.pone.0264821 Text en © 2022 Eliès et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Eliès, Antoine
Bonneau, Claire
Houzard, Sophie
Rouzier, Roman
Héquet, Delphine
Impact of catch-up human papillomavirus vaccination on cervical conization rate in a real-life population in France
title Impact of catch-up human papillomavirus vaccination on cervical conization rate in a real-life population in France
title_full Impact of catch-up human papillomavirus vaccination on cervical conization rate in a real-life population in France
title_fullStr Impact of catch-up human papillomavirus vaccination on cervical conization rate in a real-life population in France
title_full_unstemmed Impact of catch-up human papillomavirus vaccination on cervical conization rate in a real-life population in France
title_short Impact of catch-up human papillomavirus vaccination on cervical conization rate in a real-life population in France
title_sort impact of catch-up human papillomavirus vaccination on cervical conization rate in a real-life population in france
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916646/
https://www.ncbi.nlm.nih.gov/pubmed/35275961
http://dx.doi.org/10.1371/journal.pone.0264821
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