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Graves’ disease diagnosed in remnant thyroid after lobectomy for thyroid cancer

BACKGROUND: The coexistence of Graves’ disease with thyroid cancer is well-known and total thyroidectomy is recommended in such cases. However, Graves’ disease might be dormant at the time of surgery and diagnosed after lobectomy for thyroid cancer. METHODS: We assessed the incidence and clinicopath...

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Autores principales: Jin, Meihua, Jang, Ahreum, Kim, Won Gu, Kim, Tae Yong, Kim, Won Bae, Shong, Young Kee, Jeon, Min Ji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916678/
https://www.ncbi.nlm.nih.gov/pubmed/35275968
http://dx.doi.org/10.1371/journal.pone.0265332
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author Jin, Meihua
Jang, Ahreum
Kim, Won Gu
Kim, Tae Yong
Kim, Won Bae
Shong, Young Kee
Jeon, Min Ji
author_facet Jin, Meihua
Jang, Ahreum
Kim, Won Gu
Kim, Tae Yong
Kim, Won Bae
Shong, Young Kee
Jeon, Min Ji
author_sort Jin, Meihua
collection PubMed
description BACKGROUND: The coexistence of Graves’ disease with thyroid cancer is well-known and total thyroidectomy is recommended in such cases. However, Graves’ disease might be dormant at the time of surgery and diagnosed after lobectomy for thyroid cancer. METHODS: We assessed the incidence and clinicopathological characteristic of newly developed Graves’ disease after lobectomy for thyroid cancer between 2010 and 2019. RESULTS: In all, 11043 patients underwent lobectomy for thyroid cancer during the study period, and 26 (0.2%) were diagnosed with Graves’ disease during follow-up. The median age was 43.8 years, 88.5% were female, and all were euthyroid before surgery. The median time from lobectomy to the diagnosis of Graves’ disease was 3.3 years. Half of the patients were diagnosed based on thyroid function tests during routine follow-up, and others were diagnosed due to symptoms of thyrotoxicosis. Among patients who had checked preoperative thyroid autoantibodies, 61.1% showed positivity. Twenty-one (80.8%), and 2 (7.7%) patients received antithyroid drugs and radioactive iodine therapy, respectively, and 3 (11.5%) underwent completion thyroidectomy. CONCLUSION: Although rare, Graves’ disease can occur in the remnant thyroid after lobectomy. Such patients are more likely to have autoantibodies. An appropriate workup is required when hyperthyroidism is found during the follow-up of patients after lobectomy.
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spelling pubmed-89166782022-03-12 Graves’ disease diagnosed in remnant thyroid after lobectomy for thyroid cancer Jin, Meihua Jang, Ahreum Kim, Won Gu Kim, Tae Yong Kim, Won Bae Shong, Young Kee Jeon, Min Ji PLoS One Research Article BACKGROUND: The coexistence of Graves’ disease with thyroid cancer is well-known and total thyroidectomy is recommended in such cases. However, Graves’ disease might be dormant at the time of surgery and diagnosed after lobectomy for thyroid cancer. METHODS: We assessed the incidence and clinicopathological characteristic of newly developed Graves’ disease after lobectomy for thyroid cancer between 2010 and 2019. RESULTS: In all, 11043 patients underwent lobectomy for thyroid cancer during the study period, and 26 (0.2%) were diagnosed with Graves’ disease during follow-up. The median age was 43.8 years, 88.5% were female, and all were euthyroid before surgery. The median time from lobectomy to the diagnosis of Graves’ disease was 3.3 years. Half of the patients were diagnosed based on thyroid function tests during routine follow-up, and others were diagnosed due to symptoms of thyrotoxicosis. Among patients who had checked preoperative thyroid autoantibodies, 61.1% showed positivity. Twenty-one (80.8%), and 2 (7.7%) patients received antithyroid drugs and radioactive iodine therapy, respectively, and 3 (11.5%) underwent completion thyroidectomy. CONCLUSION: Although rare, Graves’ disease can occur in the remnant thyroid after lobectomy. Such patients are more likely to have autoantibodies. An appropriate workup is required when hyperthyroidism is found during the follow-up of patients after lobectomy. Public Library of Science 2022-03-11 /pmc/articles/PMC8916678/ /pubmed/35275968 http://dx.doi.org/10.1371/journal.pone.0265332 Text en © 2022 Jin et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Jin, Meihua
Jang, Ahreum
Kim, Won Gu
Kim, Tae Yong
Kim, Won Bae
Shong, Young Kee
Jeon, Min Ji
Graves’ disease diagnosed in remnant thyroid after lobectomy for thyroid cancer
title Graves’ disease diagnosed in remnant thyroid after lobectomy for thyroid cancer
title_full Graves’ disease diagnosed in remnant thyroid after lobectomy for thyroid cancer
title_fullStr Graves’ disease diagnosed in remnant thyroid after lobectomy for thyroid cancer
title_full_unstemmed Graves’ disease diagnosed in remnant thyroid after lobectomy for thyroid cancer
title_short Graves’ disease diagnosed in remnant thyroid after lobectomy for thyroid cancer
title_sort graves’ disease diagnosed in remnant thyroid after lobectomy for thyroid cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916678/
https://www.ncbi.nlm.nih.gov/pubmed/35275968
http://dx.doi.org/10.1371/journal.pone.0265332
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